Iyengar Neil M, Ghossein Ronald A, Morris Luc G, Zhou Xi K, Kochhar Amit, Morris Patrick G, Pfister David G, Patel Snehal G, Boyle Jay O, Hudis Clifford A, Dannenberg Andrew J
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Medicine, Weill Cornell Medical College, New York, New York.
Cancer. 2016 Dec 15;122(24):3794-3802. doi: 10.1002/cncr.30251. Epub 2016 Aug 10.
Obesity is associated with increased adipose tissue in the tongue. Chronic white adipose tissue (WAT) inflammation commonly occurs in the obese. We investigated whether WAT inflammation in the tongue impacts survival in patients with squamous cell carcinoma (SCC) of the oral tongue.
In a retrospective cohort study, patients with T1 and T2 SCC of the oral tongue who underwent curative-intent resection were included. Tongue WAT inflammation was defined by the presence of dead or dying adipocytes surrounded by macrophages forming crown-like structures. The primary and secondary endpoints were disease-specific survival (DSS) and overall survival (OS), respectively. Subgroup analyses were carried out in patients without lymph node involvement for whom adjuvant therapies were not indicated.
Archived tissue was available from 125 patients. The median follow-up was 55 months (range, 3-156 months). Overall, 49 of 125 patients (39%) had tongue WAT inflammation, which was associated with higher body mass index, increased tumor thickness, and vascular invasion (P < .05). The 3-year DSS rate for patients with tongue WAT inflammation was 59% (95% confidence interval [CI], 46%-76%) versus 82% (95% CI, 73%-92%) for those without inflammation. For patients without lymph node involvement for whom adjuvant therapy was not indicated (N = 70), tongue WAT inflammation was associated with shortened DSS and OS (P < .05). When adjusted for body mass index and potential prognostic covariates, the hazard ratio for DSS and OS was 5.40 (95% CI, 1.20-24.26) and 2.97 (95% CI, 1.02-8.65), respectively.
Tongue WAT inflammation is associated with worse DSS and OS in patients who have early stage SCC of the oral tongue. Cancer 2016;122:3794-3802. © 2016 American Cancer Society.
肥胖与舌部脂肪组织增加有关。慢性白色脂肪组织（WAT）炎症在肥胖者中普遍存在。我们研究了舌部WAT炎症是否会影响口腔鳞状细胞癌（SCC）患者的生存。
在一项回顾性队列研究中，纳入了接受根治性切除的口腔舌部T1和T2期SCC患者。舌部WAT炎症定义为存在被巨噬细胞包围形成冠状结构的死亡或濒死脂肪细胞。主要终点和次要终点分别为疾病特异性生存（DSS）和总生存（OS）。对未发生淋巴结转移且无需辅助治疗的患者进行亚组分析。
可获得125例患者的存档组织。中位随访时间为55个月（范围3 - 156个月）。总体而言，125例患者中有49例（39%）存在舌部WAT炎症，这与较高的体重指数、增加的肿瘤厚度和血管侵犯相关（P < 0.05）。存在舌部WAT炎症患者的3年DSS率为59%（95%置信区间[CI]，46% - 76%），而无炎症患者为82%（95% CI，73% - 92%）。对于未发生淋巴结转移且无需辅助治疗的患者（N = 70），舌部WAT炎症与缩短的DSS和OS相关（P < 0.05）。在对体重指数和潜在预后协变量进行校正后，DSS和OS的风险比分别为5.40（95% CI，1.20 - 24.26）和2.97（95% CI，1.02 - 8.65）。
舌部WAT炎症与早期口腔舌部SCC患者较差的DSS和OS相关。《癌症》2016年；122：3794 - 3802。© 2016美国癌症协会。
