Brown A E, Webster H K, Tulyayon S, Suvarnamani A, Wirtz R A, Sookto P
Department of Immunology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
J Clin Immunol. 1988 Sep;8(5):342-8. doi: 10.1007/BF00917149.
The circumsporozoite (CS) protein on the surface of sporozoites is the major target for antibody response(s) to the infective stage of the malaria parasite. Sera from malaria endemic areas contain both IgM and IgG antibodies that react with a dominant epitope in the tetrapeptide repeat region of the CS protein. In order to characterize the IgM CS antibody response in Plasmodium falciparum (PF) malaria, a prospective study was conducted in Thai Rangers. Variable IgM responses against the CS protein were detected in 81% of 47 PF-infected subjects. Similar to IgG response kinetics, IgM levels rose to a peak 6-10 days after detection of parasitemia and showed an apparent serum half-life of less than 25 days. The classic difference in isotype ratio (IgG/IgM) between primary and secondary antibody responses was observed to blood-stage, but not CS, antigens.
子孢子表面的环子孢子（CS）蛋白是针对疟原虫感染阶段抗体反应的主要靶点。疟疾流行地区的血清中含有IgM和IgG抗体，它们与CS蛋白四肽重复区域的一个显性表位发生反应。为了描述恶性疟原虫（PF）疟疾中IgM CS抗体反应的特征，在泰国士兵中进行了一项前瞻性研究。在47名感染PF的受试者中，81%检测到针对CS蛋白的可变IgM反应。与IgG反应动力学相似，IgM水平在检测到寄生虫血症后6-10天升至峰值，血清半衰期明显小于25天。在血期抗原而非CS抗原中观察到了初次和二次抗体反应之间典型的同种型比例（IgG/IgM）差异。
