Ugur Kadriye Serife, Acar Muradiye, Ozol Duygu, Dagli Elif, Oznur Murat, Kosus Aydin, Gunduz Mehmet
Department of Otolaryngology and Head and Neck Surgery, TOBB ETU Hospital, Ankara, Turkey,
Genetic Laboratory, Medical Park Göztepe Hospital, Istanbul, Turkey.
ORL J Otorhinolaryngol Relat Spec. 2019;81(1):16-23. doi: 10.1159/000490353. Epub 2018 Dec 11.
BACKGROUND/AIMS: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).
A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). There were 63 patients with OSA and 45 patients without OSA. In the OSA group, the median apnea hypopnea index (AHI) was 29.1; in the non-OSA group, the median AHI was 2.1. Blood samples were obtained from all 108 patients for the genetic analysis of the expression of TNF-α and EDN-1. PSG findings and gene expression levels were evaluated in both groups.
The median (range) age was 46 (20-81) years, BMI 24.9 (15-49), EDN-1 gene expression 0.45 (0.02-67.88) pg/µL, and TNF-α gene expression 1.71 (0.08-59.52) pg/µL. We found that EDN-1 and TNF-α gene expression levels were significantly higher in the OSA group than in the control group (p = 0.009 vs. p < 0.001).
EDN-1 and TNF-α gene expression levels were associated with the occurrence of OSA.
背景/目的：本研究旨在观察肿瘤坏死因子（TNF）-α和内皮素（EDN）-1的基因表达谱与阻塞性睡眠呼吸暂停（OSA）之间的关系。
在一家三级医疗学术中心进行的一项前瞻性横断面研究；本研究纳入了108例有打鼾和日间失眠症状的患者，研究在耳鼻喉科开展。所有患者均接受了1晚的多导睡眠图（PSG）检查。其中63例为OSA患者，45例为非OSA患者。OSA组的呼吸暂停低通气指数（AHI）中位数为29.1；非OSA组的AHI中位数为2.1。采集了所有108例患者的血样，用于TNF-α和EDN-1表达的基因分析。对两组的PSG检查结果和基因表达水平进行了评估。
年龄中位数（范围）为46（20 - 81）岁，体重指数（BMI）为24.9（15 - 49），EDN-1基因表达为0.45（0.02 - 67.88）pg/µL，TNF-α基因表达为1.71（0.08 - 59.52）pg/µL。我们发现，OSA组中EDN-1和TNF-α基因表达水平显著高于对照组（p = 0.009对比p < 0.001）。
EDN-1和TNF-α基因表达水平与OSA的发生有关。
