Takahashi Atsushi, Imaizumi Hiromichi, Hayashi Manabu, Okai Ken, Abe Kazumichi, Usami Keiji, Tanji Nobuo, Ohira Hiromasa
Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Usami Medical Clinic, Internal Medicine, Koriyama, Japan.
Sports Med Int Open. 2017 Jan 31;1(1):E2-E7. doi: 10.1055/s-0042-117875. eCollection 2017 Jan.
Exercise therapy is effective and recommended for non-alcoholic fatty liver disease (NAFLD) based on the efficacy of hepatic fat reduction. However, the efficacies of exercise therapy are based on short-term intervention. Moreover, no reports have examined whether significant reductions in serum levels of alanine aminotransferase (ALT) are achieved with exercise therapy in patients with NAFLD. The aim of this study is to assess the effects of simple resistance exercise for 24 weeks in NAFLD.
59 patients with NAFLD were assigned to a resistance exercise group ( =28) or a control group ( =31). The resistance exercise group performed 2 exercises (push-ups and squats) 3 times a week on nonconsecutive days for a trial periods of 24 weeks. Patients in the control group proceeded with regular physical activities under a restricted diet throughout the study. The effects of exercise were compared between groups after 24 weeks.
Mean ALT level, homeostasis model assessment-estimated insulin resistance index and hepatic steatosis grade were all decreased in the resistance exercise group. Changes in ALT levels correlated negatively with changes in muscle:body weight ratio in the exercise group.
These data demonstrate that 24 weeks of simple resistance exercise comprising squats and push-ups represents an effective treatment for NAFLD.
基于肝脏脂肪减少的功效，运动疗法对非酒精性脂肪性肝病（NAFLD）有效且被推荐。然而，运动疗法的功效基于短期干预。此外，尚无报告研究在NAFLD患者中运动疗法是否能显著降低血清丙氨酸氨基转移酶（ALT）水平。本研究的目的是评估简单抗阻运动对NAFLD患者进行24周的效果。
59例NAFLD患者被分为抗阻运动组（n = 28）或对照组（n = 31）。抗阻运动组在24周的试验期内，每周非连续3天进行2项运动（俯卧撑和深蹲），每项运动进行3组。对照组患者在整个研究期间在限制饮食的情况下进行常规体育活动。24周后比较两组的运动效果。
抗阻运动组的平均ALT水平、稳态模型评估估计的胰岛素抵抗指数和肝脂肪变性分级均降低。运动组中ALT水平的变化与肌肉与体重比的变化呈负相关。
这些数据表明，包括深蹲和俯卧撑在内的24周简单抗阻运动是治疗NAFLD的有效方法。
