Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Korea.
Department of Preventive Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Gut Liver. 2023 Jul 15;17(4):600-609. doi: 10.5009/gnl220345. Epub 2023 Mar 17.
BACKGROUND/AIMS: This study aimed to examine the independent and synergistic association of aerobic physical activity and resistance exercise with nonalcoholic fatty liver disease (NAFLD) using a nationwide representative database.
This was a cross-sectional study using data from the Korea National Health and Nutritional Examination Survey between 2007 and 2010. Multiple logistic regression models were used to examine the independent and synergistic (additive interaction) associations of aerobic physical activity and resistance exercise with NAFLD after adjusting for multiple covariates.
The prevalence of NAFLD was 26.2% for men and 17.6% for women. In the fully adjusted multiple logistic regression model to examine the independent association of aerobic physical activity or resistance exercise with NAFLD, the odds ratios for NAFLD were significantly decreased in both men (p=0.03) and women (p<0.01) who had highly active aerobic physical activity. Regarding the frequency of resistance exercise, the odds ratio for NAFLD was decreased in men who did resistance exercise ≥5 days per week (p=0.04), but not in women (p=0.19). However, when investigating the synergistic associations of aerobic physical activity and resistance exercise, the odds ratios for NAFLD significantly decreased when the frequency of both exercises increased together in both men (p for interaction <0.01) and women (p for interaction<0.01).
Combining aerobic physical activity and resistance exercise had a synergistic preventive association for NAFLD in Korean men and women.
背景/目的：本研究旨在使用全国代表性数据库，检查有氧运动和抗阻运动与非酒精性脂肪性肝病（NAFLD）的独立和协同关联。
这是一项使用 2007 年至 2010 年韩国国家健康和营养检查调查数据进行的横断面研究。使用多变量逻辑回归模型，在调整了多个协变量后，检查有氧运动和抗阻运动与 NAFLD 的独立和协同（相加交互）关联。
男性和女性的 NAFLD 患病率分别为 26.2%和 17.6%。在调整后的多变量逻辑回归模型中，对于男性（p=0.03）和女性（p<0.01），高度活跃的有氧运动与 NAFLD 的独立关联，NAFLD 的比值比显著降低。对于抗阻运动的频率，每周进行≥5 天抗阻运动的男性（p=0.04），NAFLD 的比值比降低，但女性（p=0.19）则没有。然而，当调查有氧运动和抗阻运动的协同关联时，在男性（p 交互<0.01）和女性（p 交互<0.01）中，当两种运动的频率同时增加时，NAFLD 的比值比显著降低。
在韩国男性和女性中，将有氧运动和抗阻运动相结合具有协同预防 NAFLD 的作用。
