Riedel K G
Augenklinik der Ludwig-Maximilians-Universität München.
Klin Monbl Augenheilkd. 1988 Aug;193(2):131-7. doi: 10.1055/s-2008-1050233.
Since more than a century ago, temperatures above 40 degrees C have been known to be effective in cancer treatment. Since that time numerous studies have documented that hyperthermia alone causes tumor regression and that the therapeutic effect depends on the amount and duration of heat delivered to a malignant tumor. However, after it was shown that heat combined with irradiation or chemotherapy potentiates the effect of hyperthermia, both thermoradiotherapy and thermochemotherapy were applied in experimental and clinical studies in several medical specialties. In ophthalmic oncology both retinoblastoma and uveal melanoma are treated by irradiation combined with local hyperthermia. In the present paper the use of ultrasound and microwave energy as locally applicable heat sources in intraocular malignancies is described and their suitability discussed. As is the case with malignant skin tumors and malignant tumors of the gastrointestinal and urogenital systems, malignant ocular tumors are accessible to externally applied heat and can thus be treated well by ultrasound and microwave hyperthermia. On the basis of experimental and clinical results gained with both ultrasound and microwave energy the advantages and drawbacks of these two technical modalities in intraocular tumor therapy are pointed out.
一个多世纪以来，人们就知道40摄氏度以上的温度对癌症治疗有效。从那时起，大量研究表明，单纯热疗可导致肿瘤消退，且治疗效果取决于传递至恶性肿瘤的热量的量和持续时间。然而，在证实热疗与放疗或化疗联合可增强热疗效果后，热放疗和热化疗在多个医学专科的实验和临床研究中均有应用。在眼科肿瘤学中，视网膜母细胞瘤和葡萄膜黑色素瘤均采用放疗联合局部热疗进行治疗。本文描述了超声和微波能量作为眼内恶性肿瘤局部适用热源的应用，并讨论了它们的适用性。与恶性皮肤肿瘤以及胃肠道和泌尿生殖系统的恶性肿瘤一样，恶性眼肿瘤可接受外部施加的热量，因此可通过超声和微波热疗得到良好治疗。基于超声和微波能量所获得的实验和临床结果，指出了这两种技术方式在眼内肿瘤治疗中的优缺点。
