对患有球孢子菌病的犬进行抗体检测时，ERC-2 酵母相裂解抗原的潜在临床应用。

Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis.

机构信息

Department of Biological Sciences, Idaho State University, Pocatello, Idaho, USA.

D-Lab, University of California, Berkeley, Berkeley, California, USA.

出版信息

Med Mycol. 2019 Oct 1;57(7):893-896. doi: 10.1093/mmy/myy137.

DOI:10.1093/mmy/myy137

PMID:30544205

Abstract

Four Blastomyces antigens ERC-2 (B. gilchristii, dog, Wisconsin), B5929 (human, Minnesota), 597 (human, Wisconsin), and T-27 (polar bear, Tennessee) were tested against 31 serum specimens from dogs with blastomycosis and 19 from healthy dogs. All antigens detected antibody; efficacy varied. ERC-2 showed the highest ELISA mean absorbance value of 3.00 followed by T-27. Test performance varied by sample geographic origin. Further study is needed to determine if ERC-2 antigens may be clinically useful, and whether the combination of the particular fungal species as antigen source, host animal, and the species and geographic location of the patient being tested is important for optimum test characteristics.

摘要

四种博氏接合菌抗原 ERC-2（吉尔克里斯特博氏菌、狗、威斯康星州）、B5929（人、明尼苏达州）、597（人、威斯康星州）和 T-27（北极熊、田纳西州）与 31 份患有球孢子菌病的狗血清标本和 19 份健康狗血清标本进行了检测。所有抗原均检测到抗体；疗效不同。ERC-2 的 ELISA 平均吸光度值最高，为 3.00，其次是 T-27。测试性能因样本来源地而异。需要进一步研究以确定 ERC-2 抗原是否具有临床应用价值，以及抗原来源的特定真菌种类、宿主动物以及被检测患者的物种和地理位置是否对最佳测试特性很重要。