Department of Pharmacy, East West University, Dhaka 1212, Bangladesh.
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Molecules. 2018 Dec 11;23(12):3288. doi: 10.3390/molecules23123288.
As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a strain, which is associated with the plant Schott. FUS showed rapid and sub-micromolar IC against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.
作为我们正在进行的内生真菌研究的一部分，我们从一株与植物 Schott 相关的菌株中分离出一种倍半萜霉菌毒素——呋甾烯醇（FUS）。FUS 对胰腺癌细胞系表现出快速的亚微米级 IC50 抑制活性。时间依赖性生存分析和显微镜成像显示，在与 FUS 孵育 4 小时后，癌细胞系发生快速形态变化。这为进一步开发针对胰腺癌的更有效合成剂提供了新的化学结构。
