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B-cell lymphomas present immunoglobulin neoantigens.

作者信息

Khodadoust Michael S, Olsson Niclas, Chen Binbin, Sworder Brian, Shree Tanaya, Liu Chih Long, Zhang Lichao, Czerwinski Debra K, Davis Mark M, Levy Ronald, Elias Joshua E, Alizadeh Ash A

机构信息

Division of Oncology, Department of Medicine.

Department of Chemical and Systems Biology.

出版信息

Blood. 2019 Feb 21;133(8):878-881. doi: 10.1182/blood-2018-06-845156. Epub 2018 Dec 13.

DOI:10.1182/blood-2018-06-845156
PMID:30545830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6384186/
Abstract
摘要

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Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma.免疫球蛋白独特型序列预测 HLA 结合的比较分析表明滤泡性淋巴瘤中 T 细胞介导的免疫监视。
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Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma.TLR9 激动剂疫苗接种联合局部低剂量照射诱导惰性淋巴瘤的全身反应。
Cancer Discov. 2018 Oct;8(10):1258-1269. doi: 10.1158/2159-8290.CD-18-0743. Epub 2018 Aug 28.
2
Prediction Analysis of Idiotope-Driven T-B Cell Collaboration in Multiple Sclerosis.多发性硬化症中独特型驱动的T-B细胞协作的预测分析
Front Immunol. 2017 Oct 2;8:1255. doi: 10.3389/fimmu.2017.01255. eCollection 2017.
3
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.抗原呈递分析揭示了对淋巴瘤免疫球蛋白新抗原的识别。
Nature. 2017 Mar 30;543(7647):723-727. doi: 10.1038/nature21433. Epub 2017 Mar 22.
4
Targeting B-cell malignancies through human B-cell receptor specific CD4 T cells.通过人B细胞受体特异性CD4 T细胞靶向B细胞恶性肿瘤。
Oncoimmunology. 2016 Sep 19;5(11):e1232220. doi: 10.1080/2162402X.2016.1232220. eCollection 2016.
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Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.通过质谱直接鉴定天然人黑色素瘤组织上呈现的临床相关新表位。
Nat Commun. 2016 Nov 21;7:13404. doi: 10.1038/ncomms13404.
6
Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.利用HLA肽组学和全外显子组测序鉴定人类免疫原性新抗原。
Oncotarget. 2016 Feb 2;7(5):5110-7. doi: 10.18632/oncotarget.6960.
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The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell-based immunotherapy.多发性骨髓瘤的抗原格局:质谱分析(重新)定义基于T细胞的免疫疗法的靶点。
Blood. 2015 Sep 3;126(10):1203-13. doi: 10.1182/blood-2015-04-640532. Epub 2015 Jul 2.
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HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL).HLA配体组分析确定了慢性淋巴细胞白血病(CLL)中自发抗白血病免疫反应的潜在特异性。
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E166-75. doi: 10.1073/pnas.1416389112. Epub 2014 Dec 29.
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Frequency Patterns of T-Cell Exposed Amino Acid Motifs in Immunoglobulin Heavy Chain Peptides Presented by MHCs.T 细胞暴露的氨基酸基序在 MHC 呈递的免疫球蛋白重链肽中的频率模式。
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Active idiotypic vaccination versus control immunotherapy for follicular lymphoma.滤泡性淋巴瘤的主动独特型疫苗接种与对照免疫疗法
J Clin Oncol. 2014 Jun 10;32(17):1797-803. doi: 10.1200/JCO.2012.43.9273. Epub 2014 May 5.