急性髓性白血病患者的自体白血病特异性T细胞介导的淋巴细胞毒性
Autologous leukemia-specific T-cell-mediated lymphocytotoxicity in patients with acute myelogenous leukemia.
作者信息
Lee S K, Oliver R T
出版信息
J Exp Med. 1978 Mar 1;147(3):912-22. doi: 10.1084/jem.147.3.912.
Abstract
Short-term culture of acute myelogenous leukemia patient's remission lymphocytes with inactivated autologous leukemic blast cells plus allogeneic lymphocytes, generated effector T lymphocytes which were cytotoxic for the specific autologous blast cell in 11 of 14 patients studied. Experiments using Daudi and Molt 4 lymphoblastoid cell lines as third-party helper cell suggest that an HLA D locus incompatability is necessary to provide effective help in this system. Cold target inhibition experiments, crossover studies between pairs of patients, and experiments with allogeneic leukemic blast cells as priming stimulus suggest that the target antigen is only present on the specific autologous blast cell.
摘要
用灭活的自体白血病原始细胞加异基因淋巴细胞对急性髓性白血病患者的缓解期淋巴细胞进行短期培养，在所研究的14例患者中，有11例产生了对特定自体原始细胞具有细胞毒性的效应T淋巴细胞。使用Daudi和Molt 4淋巴母细胞系作为第三方辅助细胞的实验表明，HLA D位点不相容性是在该系统中提供有效辅助所必需的。冷靶抑制实验、患者对之间的交叉研究以及以异基因白血病原始细胞作为启动刺激的实验表明，靶抗原仅存在于特定的自体原始细胞上。
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