从急性白血病患者中采集白血病细胞用作免疫疗法的安全方法。
Safe method of collecting leukaemia cells from patients with acute leukaemia for use as immunotherapy.
作者信息
Powles R L, Lister T A, Oliver R T, Russell J, Smith C, Kay H E, McElwain T J, Fairley G H
出版信息
Br Med J. 1974 Nov 16;4(5941):375-9. doi: 10.1136/bmj.4.5941.375.
Abstract
Leukaemia cells were collected from the blood of 72 untreated patients using a continuous-flow blood cell separator. The yield of cells was proportional to the number circulating in the patient, and up to 1 x 10(12) could be obtained in three hours. Complications of the procedure were mild, consisting of chills and shivering in 18% of patients. Leucopheresis at the time of diagnosis is an essential part of setting up a specific immunotherapy programme for patients with acute myelogenous leukaemia, and the lack of harmful side effects makes the collection of these cells ethically justified. The need for a centralized service to provide cells for this form of therapy is emphasized.
摘要
使用连续流动血细胞分离器从72名未经治疗的患者血液中采集白血病细胞。细胞产量与患者体内循环的细胞数量成正比，三小时内可获得多达1×10¹²个细胞。该操作的并发症较轻，18%的患者出现寒战和颤抖。诊断时进行白细胞去除术是为急性髓性白血病患者建立特定免疫治疗方案的重要组成部分，且缺乏有害副作用使得采集这些细胞在伦理上是合理的。强调了需要一个集中服务机构来为这种治疗形式提供细胞。
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