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T2Bacteria magnetic resonance assay for the rapid detection of ESKAPEc pathogens directly in whole blood.T2Bacteria 磁共振检测法可直接从全血中快速检测 ESKAPEE 病原菌。
J Antimicrob Chemother. 2018 Mar 1;73(suppl_4):iv20-iv26. doi: 10.1093/jac/dky049.
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Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples.多中心评价生物梅里埃 FilmArray 呼吸道Panel 2 检测鼻咽拭子样本中病毒和细菌
J Clin Microbiol. 2018 May 25;56(6). doi: 10.1128/JCM.01945-17. Print 2018 Jun.
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Point-Counterpoint: Meningitis/Encephalitis Syndromic Testing in the Clinical Laboratory.观点对垒：临床实验室中的脑膜炎/脑炎综合征检测。
J Clin Microbiol. 2018 Mar 26;56(4). doi: 10.1128/JCM.00018-18. Print 2018 Apr.
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Expert Rev Mol Diagn. 2018 Feb;18(2):119-132. doi: 10.1080/14737159.2018.1420476. Epub 2017 Dec 28.
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Clinical implications of rapid ePlex® Respiratory Pathogen Panel testing compared to laboratory-developed real-time PCR.快速 ePlex® 呼吸道病原体检测与实验室开发的实时 PCR 相比的临床意义。
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6
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J Clin Microbiol. 2018 Jan 24;56(2). doi: 10.1128/JCM.01658-17. Print 2018 Feb.
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2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea.2017 年美国传染病学会临床实践指南：感染性腹泻的诊断和管理。
Clin Infect Dis. 2017 Nov 29;65(12):1963-1973. doi: 10.1093/cid/cix959.
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Syndromic Panel-Based Testing in Clinical Microbiology.基于综合征的临床微生物学检测面板。
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Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use.多重聚合酶链反应即时检测与常规实验室检测在成人呼吸道感染治疗中的比较：一项评估对住院时间和抗菌药物使用影响的半随机研究
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Comparison of the Luminex NxTAG respiratory pathogen panel and a multiplex in-house real-time PCR panel for the detection of respiratory viruses in symptomatic patients.Luminex NxTAG呼吸道病原体检测板与内部多重实时PCR检测板在有症状患者中检测呼吸道病毒的比较。
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GenMark ePlex：感染诊断症候群武器库中的又一利器。

The GenMark ePlex: another weapon in the syndromic arsenal for infection diagnosis.

机构信息

Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center & School of Medicine, Nashville, TN 37232, USA.

Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065 USA.

出版信息

Future Microbiol. 2018 Dec;13(16):1697-1708. doi: 10.2217/fmb-2018-0258. Epub 2018 Dec 14.

DOI:10.2217/fmb-2018-0258
PMID:30547684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6439521/
Abstract

As one of the most recent additions to the syndromic testing landscape, the ePlex platform by GenMark Diagnostics is a system that combines the manufacturer's signature electrochemical detection technology with updated microfluidics, providing a new option for multiplex testing that is both rapid and requires minimal hands-on steps. In this review, we detail the ePlex platform and its current/future syndromic panels, with a particular focus on the respiratory pathogen panel - the platform's first assay to undergo clinical trials and receive regulatory approval in the USA. By keeping informed of these ever-expanding laboratory options, clinicians and microbiologists can stay positioned at the forefront of infectious disease diagnosis.

摘要

作为最新加入综合征检测领域的产品之一，GenMark Diagnostics 的 ePlex 平台是一种将制造商的标志性电化学检测技术与更新的微流控技术相结合的系统，为快速且需要最少手动步骤的多重检测提供了新的选择。在这篇综述中，我们详细介绍了 ePlex 平台及其当前/未来的综合征检测试剂盒，特别关注呼吸道病原体检测试剂盒——这是该平台的首个进行临床试验并获得美国监管机构批准的检测试剂盒。通过了解这些不断扩展的实验室检测选项，临床医生和微生物学家可以站在传染病诊断的最前沿。