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电化学生物传感器在 COVID-19 大流行中的潜在应用:对 SARS-CoV-2 快速诊断的展望。

The potential application of electrochemical biosensors in the COVID-19 pandemic: A perspective on the rapid diagnostics of SARS-CoV-2.

机构信息

Biological Sciences Department, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada.

Department of Bioengineering, McGill University, Montréal, QC, H3A 0C3, Canada.

出版信息

Biosens Bioelectron. 2021 Mar 15;176:112905. doi: 10.1016/j.bios.2020.112905. Epub 2020 Dec 17.

Abstract

Electrochemical biosensors combine the selectivity of electrochemical signal transducers with the specificity of biomolecular recognition strategies. Although they have been broadly studied in different areas of diagnostics, they are not yet fully commercialized. During the COVID-19 pandemic, electrochemical platforms have shown the potential to address significant limitations of conventional diagnostic platforms, including accuracy, affordability, and portability. The advantages of electrochemical platforms make them a strong candidate for rapid point-of-care detection of SARS-CoV-2 infection by targeting not only viral RNA but antigens and antibodies. Herein, we reviewed advancements in electrochemical biosensing platforms towards the detection of SARS-CoV-2 through studying similar viruses.

摘要

电化学生物传感器将电化学信号转换器的选择性与生物分子识别策略的特异性相结合。尽管它们已经在不同的诊断领域得到了广泛研究,但它们尚未完全商业化。在 COVID-19 大流行期间,电化学平台已经显示出解决传统诊断平台的重大局限性的潜力,包括准确性、可负担性和便携性。电化学平台的优势使其成为通过针对不仅是病毒 RNA 而且是抗原和抗体来快速进行 SARS-CoV-2 感染的即时检测的有力候选者。在此,我们通过研究类似病毒来综述了电化学生物传感平台在检测 SARS-CoV-2 方面的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/151d/7746140/8ef5e307ca6a/sc1_lrg.jpg

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