DNA中的错配形成可能涉及模板中罕见的互变异构形式。
Mispair formation in DNA can involve rare tautomeric forms in the template.
作者信息
Strazewski P
机构信息
Institut für organische Chemie, Basel, Switzerland.
出版信息
Nucleic Acids Res. 1988 Oct 25;16(20):9377-98. doi: 10.1093/nar/16.20.9377.
Abstract
The formation of pyridine-pyrimidine- and pyrimidine-pyrimidine base pairs after in vitro DNA replication with the large fragment of Escherichia coli DNA polymerase I indicates that Watson-Crick-like base pairing between pyrimidine bases can occur in the enzyme due to the presence of the rare tautomers of deoxycytidylate and thymidylate in the template strand. The implications to mispair formation in DNA, such as the difference between the structures of the mispairs during and after replication, are discussed and the possible action of mutagenic DNA protonating and deprotonating agents in vivo is considered.
摘要
用大肠杆菌DNA聚合酶I大片段进行体外DNA复制后形成的吡啶 - 嘧啶和嘧啶 - 嘧啶碱基对表明，由于模板链中脱氧胞苷酸和胸苷酸的稀有互变异构体的存在，嘧啶碱基之间可以发生类似沃森 - 克里克的碱基配对。文中讨论了这对DNA错配形成的影响，例如复制期间和之后错配结构的差异，并考虑了体内诱变DNA质子化和去质子化剂的可能作用。
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