Fölsch U R, Fussek M, Ebert R, Creutzfeldt W
Department of Medicine, Georg-August-Universität, Göttingen, F.R.G.
Pancreas. 1988;3(5):536-42. doi: 10.1097/00006676-198810000-00005.
Serum levels of glucose, insulin, and gastric inhibitory polypeptide (GIP) in response to intraduodenal and intravenous glucose loads have been examined in rats with exocrine pancreatic atrophy induced by feeding them a copper-deficient diet supplemented with D-penicillamine for 10-12 weeks. Whereas pancreatic weight and protein and trypsin content were drastically reduced as compared with pair-fed controls, insulin content was not significantly different between experimental (1.10 U) and control (1.40 U) rats. The intravenous glucose infusion was given in a dose (1.2 g/kg/h) simulating the glucose concentrations observed in response to an intraduodenal glucose load of 2.0 g/kg body weight. Both basal and stimulated insulin concentrations were lower in experimental animals as compared with controls. However, if the relative insulin response is considered, insulin secretion was almost identical in experimental and control animals. Both groups released significantly more insulin after intraduodenal glucose load than after intravenous glucose application. It is concluded that the entero-insular axis is intact in rats with exocrine pancreatic atrophy.
通过给大鼠喂食含D-青霉胺的缺铜饮食10 - 12周诱导外分泌胰腺萎缩，然后检测了这些大鼠在十二指肠内和静脉内注射葡萄糖负荷后血清葡萄糖、胰岛素和胃抑制多肽（GIP）的水平。与配对喂养的对照组相比，胰腺重量、蛋白质和胰蛋白酶含量显著降低，但实验大鼠（1.10 U）和对照大鼠（1.40 U）的胰岛素含量无显著差异。静脉内输注葡萄糖的剂量为（1.2 g/kg/h），模拟十二指肠内给予2.0 g/kg体重葡萄糖负荷后观察到的葡萄糖浓度。与对照组相比，实验动物的基础胰岛素浓度和刺激后胰岛素浓度均较低。然而，如果考虑相对胰岛素反应，实验动物和对照动物的胰岛素分泌几乎相同。两组在十二指肠内给予葡萄糖负荷后释放的胰岛素均明显多于静脉内给予葡萄糖后。结论是外分泌胰腺萎缩的大鼠肠-胰岛轴完整。
