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Targeting Transforming Growth Factor Beta Signaling in Liver Cancer.

作者信息

Rao Shuyun, Mishra Lopa

机构信息

Center for Translational Medicine, Department of Surgery, George Washington University, Washington, DC.

Department of Medicine, Institute of Clinical Research, Veterans Affairs Medical Center, Washington, DC.

出版信息

Hepatology. 2019 Apr;69(4):1375-1378. doi: 10.1002/hep.30426. Epub 2019 Mar 5.

DOI:10.1002/hep.30426
PMID:30549280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6854682/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9894/6854682/84748df52e9f/nihms-1046142-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9894/6854682/84748df52e9f/nihms-1046142-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9894/6854682/84748df52e9f/nihms-1046142-f0001.jpg

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本文引用的文献

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A Transforming Growth Factor-β and H19 Signaling Axis in Tumor-Initiating Hepatocytes That Regulates Hepatic Carcinogenesis.肿瘤起始肝细胞中的转化生长因子-β和 H19 信号轴调控肝肿瘤发生。
Hepatology. 2019 Apr;69(4):1549-1563. doi: 10.1002/hep.30153. Epub 2018 Dec 31.
2
Long noncoding RNA H19 promotes transforming growth factor-β-induced epithelial-mesenchymal transition by acting as a competing endogenous RNA of miR-370-3p in ovarian cancer cells.长链非编码RNA H19通过作为卵巢癌细胞中miR-370-3p的竞争性内源性RNA来促进转化生长因子-β诱导的上皮-间质转化。
Onco Targets Ther. 2018 Jan 18;11:427-440. doi: 10.2147/OTT.S149908. eCollection 2018.
3
Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway.肝细胞癌基因组和转录组分析确定了转化生长因子-β信号通路中的突变和基因表达变化。
Gastroenterology. 2018 Jan;154(1):195-210. doi: 10.1053/j.gastro.2017.09.007. Epub 2017 Sep 15.
4
Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail.转化生长因子-β 通过上调 Snail 促进小鼠肝癌发生。
Gastroenterology. 2017 Nov;153(5):1378-1391.e6. doi: 10.1053/j.gastro.2017.07.014. Epub 2017 Jul 20.
5
TGF-β Tumor Suppression through a Lethal EMT.通过致死性上皮-间质转化实现的转化生长因子-β肿瘤抑制作用
Cell. 2016 Feb 25;164(5):1015-30. doi: 10.1016/j.cell.2016.01.009. Epub 2016 Feb 18.
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TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.转化生长因子-β/β2-血影蛋白/CCCTC结合因子调控人类干细胞疾病贝克威思-维德曼综合征中的肿瘤抑制作用。
J Clin Invest. 2016 Feb;126(2):527-42. doi: 10.1172/JCI80937. Epub 2016 Jan 19.
7
TGFbeta in Cancer.癌症中的转化生长因子β
Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.