Ritter Amit, Bachar Gideon, Feinmesser Raphael, Shpitzer Thomas, Popovtzer Aron, Rabinovics Naomi
Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.
Institute of Oncology, Davidoff Center, Rabin Medical Center, Petach Tikva, Israel.
Head Neck. 2019 Feb;41(2):374-380. doi: 10.1002/hed.25467. Epub 2018 Dec 14.
Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck.
A retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck.
Of 3339 organ recipients, 259 patients developed 697 head and neck NMSC. Squamous cell carcinoma was the most common malignancy (55%). The overall 5-year and 10-year survival was 68% and 45%. Kidney recipients had better survival outcome than other organ recipients (10 vs 7 years). Advanced-stage cancers (10%), aggressive patterns of tumors (21%), and treatment with Prograf and Cellcept were associated with increased disease-specific mortality.
Solid organ transplant increases the risk of NMSC of the head and neck. Aggressive tumors decrease patient survival and warrant more decisive and multidisciplinary approach.
非黑色素瘤皮肤癌（NMSC）是实体器官移植受者中最常见的恶性肿瘤。我们调查了头颈部发生NMSC的实体器官移植受者的发病率、临床特征及预后情况。
对1992年至2015年接受治疗且发生头颈部NMSC的实体器官移植受者进行回顾性病历审查。
在3339名器官移植受者中，259例患者发生了697例头颈部NMSC。鳞状细胞癌是最常见的恶性肿瘤（55%）。总体5年和10年生存率分别为68%和45%。肾移植受者的生存结果优于其他器官移植受者（分别为10年和7年）。晚期癌症（10%）、侵袭性肿瘤模式（21%）以及使用普乐可复和骁悉治疗与疾病特异性死亡率增加相关。
实体器官移植增加了头颈部发生NMSC的风险。侵袭性肿瘤会降低患者生存率，需要采取更果断的多学科方法。
