Badrick Tony, Cervinski Mark, Loh Tze Ping
RCPA Quality Assurance Programs, Sydney, NSW, Australia.
Dartmouth-Hitchcock Medical Center, New Hampshire, USA.
Clin Biochem. 2019 Feb;64:1-5. doi: 10.1016/j.clinbiochem.2018.12.004. Epub 2018 Dec 11.
Patient-based Quality Control techniques have been described for more than fifty years and have been widely used routinely in hematology for forty. However, because of practical issues they have not been widely utilised in clinical chemistry laboratories. But recently because of the availability of middleware and a greater appreciation of the benefits of these processes there has been a willingness to investigate their use as a QC tool.
This Review describes the development of various patient-based quality control techniques from the earliest Average of Normals approach including the Moving Average, Moving Median and Moving Sum of Outliers. Variations such as weighting, transformation and annealing are discussed. Integrating patient-based QC and conventional QC is discussed as the problem of sub-populations.
Patient-based QC methods will become more widespread as their benefits are more fully understood and middleware becomes available that allows laboratories to implement these techniques with their patient populations.
基于患者的质量控制技术已被描述五十多年，在血液学领域常规广泛使用已有四十年。然而，由于实际问题，它们尚未在临床化学实验室中广泛应用。但最近，由于中间件的可用性以及对这些流程益处的更深入认识，人们愿意研究将其用作质量控制工具。
本综述描述了从最早的正常均值法发展而来的各种基于患者的质量控制技术，包括移动均值、移动中位数和异常值移动总和。还讨论了加权、变换和退火等变体。作为亚群问题，讨论了整合基于患者的质量控制和传统质量控制。
随着基于患者的质量控制方法的益处得到更充分理解，并且有了使实验室能够针对其患者群体实施这些技术的中间件，基于患者的质量控制方法将变得更加普遍。
