Bégin R, Massé S, Cantin A, Bisson G, Bergeron D
Centre Hospitalier Universitaire, Sherbrooke, Québec, Canada.
Rev Mal Respir. 1988;5(5):417-28.
Much recent work in thoracic medicine has been slanted towards the early detection of respiratory disease and the prevention of disabling sequelae. In the field of pneumoconioses associated with inhalation of mineral dust the interest of research workers has been largely orientated towards the objectives of early detection and the prevention of fibrotic scarring. To achieve real progress the research workers have used new investigational techniques such as axial tomography of the thorax, quantitative scintigraphy using Gallium-67 and analyses of bronchiolar lavage in parallel with a traditional approach, namely: a clinical examination of the patient, a pulmonary radiograph and respiratory function tests. These studies have enabled further clarification of the specific value of each of these new methods of investigation, whether at the level of early detection, the early recognition of pulmonary fibrosis, the characterisation of the current state of the disease and the prediction of fibrogenic power. Several different forms of intervention on the fibrotic process are currently under trial and may contribute to the prevention of pulmonary fibrosis.
近年来，胸科医学的许多工作都倾向于呼吸系统疾病的早期检测以及致残后遗症的预防。在与吸入矿物粉尘相关的尘肺病领域，研究人员的兴趣主要集中在早期检测和预防纤维化瘢痕形成的目标上。为了取得实际进展，研究人员采用了新的研究技术，如胸部轴向断层扫描、使用镓 - 67的定量闪烁扫描以及支气管肺泡灌洗分析，并与传统方法并行，即：对患者进行临床检查、肺部X光片检查和呼吸功能测试。这些研究能够进一步阐明这些新研究方法中每一种方法的具体价值，无论是在早期检测、肺纤维化的早期识别、疾病当前状态的特征描述还是纤维化能力的预测方面。目前正在试验几种针对纤维化过程的不同干预形式，它们可能有助于预防肺纤维化。
