在东亚人群中，烟草使用、饮酒、咀嚼槟榔与头颈部癌症的风险。
Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.
机构信息
Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
Departments of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
Head Neck. 2019 Jan;41(1):92-102. doi: 10.1002/hed.25383. Epub 2018 Dec 15.
BACKGROUND
The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.
METHODS
A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression.
RESULTS
Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer.
CONCLUSIONS
Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S.
背景
中国男性的吸烟率很高，但头颈部癌症的发病率却很低。本研究旨在探讨烟草、槟榔和酒精对头颈部癌症风险在东亚的影响。
方法
在东亚进行了一项多中心病例对照研究（921 例头颈部癌症患者和 806 例对照）。使用逻辑回归估计比值比（OR）和 95％置信区间（CI）。
结果
头颈部癌症的风险因烟草（OR=1.58）、槟榔（OR=8.23）和酒精（OR=2.29）而升高。烟草和/或酒精的总归因风险为 47.2％。烟草/酒精似乎在女性中的头颈部癌症中占很小的比例（归因风险为 2.2％）。仅嚼槟榔就占头颈部癌症的 28.7％。
结论
在本中国人群中，嚼槟榔是口腔癌的最强危险因素。与欧洲或美国人群相比，酒精在该人群中对头颈部癌症的作用可能更大。
Zotero 插件