Department of Oncology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Head Neck. 2019 Jan;41(1):239-247. doi: 10.1002/hed.25468. Epub 2018 Dec 15.
Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. In this article, we provide a comprehensive review of recent breakthroughs, preliminary results of novel therapy, and future directions on the treatment of these complex malignancies.
唾液腺癌是一组罕见的肿瘤，由 20 多种组织学亚型组成。最初被视为一种单一的疾病，其诊断、预后和治疗目前正在根据形态学进行分层。最近，对每个亚型的分子特征有了更深入的了解，进一步提高了诊断的准确性，并为个性化治疗铺平了道路。本文综述了这些复杂恶性肿瘤治疗方面的最新突破、新疗法的初步结果和未来方向。
