Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden; Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Rheumatology and Molecular Skeletal Biology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Osteoarthritis Cartilage. 2019 Mar;27(3):476-483. doi: 10.1016/j.joca.2018.12.003. Epub 2018 Dec 12.
To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA).
We sampled medial and lateral menisci from ten medial compartment knee OA patients (mean age 63 years) undergoing total knee replacement and from ten deceased donors (references, mean age 51 years). MR relaxation parameters T2*, T2 and T1 of the posterior horn were measured at a 9.4 T scanner. Comparisons were made between OA patients and references (with adjustment for age) as well as between medial and lateral menisci from the same knees.
Mean values (standard deviation) of mean T2* were 13 (3.8), 6.9 (2.3), 7.2 (1.9) and 7.2 (1.7) ms for the medial and lateral patient menisci and the medial and lateral reference menisci, respectively. Corresponding values were 17 (3.7), 9.0 (2.2), 12 (4) and 9.0 (1.3) ms for T2 and 1810 (150), 1630 (30), 1580 (90) and 1560 (50) ms for T1. All three relaxation times were significantly longer in medial OA menisci compared to the other groups. Among medial reference menisci, relaxation times (mainly T1) tended to increase with age.
MR relaxation times T2*, T2 and T1 in the posterior horn are longer in the medial menisci of patients with end-stage medial compartment knee OA compared to the corresponding lateral menisci and to reference menisci. The meniscus seems to undergo intrasubstance alterations related to both OA and ageing.
通过对膝骨关节炎（OA）患者和非 OA 患者膝关节内侧和外侧半月板后角进行定量磁共振成像，研究半月板磁共振（MR）弛豫参数与半月板退变之间的关系。
我们从 10 例接受全膝关节置换术的内侧间室膝 OA 患者（平均年龄 63 岁）和 10 例已故供体（参考组，平均年龄 51 岁）中取样获取内侧和外侧半月板。在 9.4 T 扫描仪上测量后角的 T2*、T2 和 T1 弛豫参数。OA 患者与参考组（年龄调整）以及同一膝关节的内侧和外侧半月板之间进行了比较。
内侧和外侧患者半月板以及内侧和外侧参考半月板的平均 T2*均值（标准差）分别为 13（3.8）、6.9（2.3）、7.2（1.9）和 7.2（1.7）ms。相应的 T2 值分别为 17（3.7）、9.0（2.2）、12（4）和 9.0（1.3）ms，T1 值分别为 1810（150）、1630（30）、1580（90）和 1560（50）ms。内侧 OA 半月板的三种弛豫时间均明显长于其他组。在内侧参考半月板中，弛豫时间（主要是 T1）随着年龄的增长而趋于增加。
与相应的外侧半月板和参考半月板相比，终末期内侧间室膝 OA 患者的内侧半月板后角的 MR 弛豫时间 T2*、T2 和 T1 较长。半月板似乎发生了与 OA 和老化相关的内部改变。
