Laboratoire Signalisation Fonctionnelle des Canaux Ioniques et Récepteurs (SiFCIR), UPRES-EA 2647, USC INRA 1330, SFR 4207 QUASAV, UFR Sciences, Université d'Angers, 2 Boulevard Lavoisier, F-49045 Angers Cedex, France.
Laboratoire Signalisation Fonctionnelle des Canaux Ioniques et Récepteurs (SiFCIR), UPRES-EA 2647, USC INRA 1330, SFR 4207 QUASAV, UFR Sciences, Université d'Angers, 2 Boulevard Lavoisier, F-49045 Angers Cedex, France.
Curr Opin Insect Sci. 2018 Dec;30:52-58. doi: 10.1016/j.cois.2018.09.007. Epub 2018 Sep 27.
Integrated Pest Management and Integrated Vector Management worldwide are developed in agriculture and public health to counteract and limit the exponential increasing development of insect resistance to insecticides. However, facing the predominance of some resistant populations, new strategies are urgently needed to target resistant insects. An innovative approach lies in the optimization of commonly used insecticides when combined with chemical or biological synergistic agents. By an increase of intracellular calcium concentration followed by activation of calcium-dependant signalling pathways, the synergistic agents are able to indirectly increase target sites sensitivity to insecticide by inducing conformational change. The synergistic agents are of great interest in optimizing the efficacy of insecticides and in overcoming resistance mechanisms.
全球范围内的有害生物综合治理和病媒综合管理是在农业和公共卫生领域发展起来的，以对抗和限制昆虫对杀虫剂的抗药性呈指数级增长。然而，面对一些具有抗性的种群占主导地位的情况，迫切需要新的策略来针对具有抗性的昆虫。一种创新的方法在于优化常用杀虫剂，同时结合化学或生物增效剂。增效剂通过增加细胞内钙离子浓度，随后激活钙依赖性信号通路，能够通过诱导构象变化，间接地增加杀虫剂对靶标部位的敏感性。增效剂在优化杀虫剂的功效和克服抗性机制方面具有很大的兴趣。
