University Angers, INRAE, SIFCIR, SFR QUASAV, F-49045 Angers, France.
DGIMI, University of Montpellier, INRAE, F-34095 Montpellier, France.
Viruses. 2022 Apr 30;14(5):943. doi: 10.3390/v14050943.
Among novel strategies proposed in pest management, synergistic agents are used to improve insecticide efficacy through an elevation of intracellular calcium concentration that activates the calcium-dependent intracellular pathway. This leads to a changed target site conformation and to increased sensitivity to insecticides while reducing their concentrations. Because virus-like particles (VLPs) increase the intracellular calcium concentration, they can be used as a synergistic agent to synergize the effect of insecticides. VLPs are self-assembled viral protein complexes, and by contrast to entomopathogen viruses, they are devoid of genetic material, which makes them non-infectious and safer than viruses. Although VLPs are well-known to be used in human health, we propose in this study the development of a promising strategy based on the use of VLPs as synergistic agents in pest management. This will lead to increased insecticides efficacy while reducing their concentrations.
在害虫管理中提出的新策略中，增效剂被用于通过提高细胞内钙浓度来提高杀虫剂的功效，从而激活依赖钙的细胞内途径。这导致靶标部位构象发生变化，对杀虫剂的敏感性增加，同时降低其浓度。由于病毒样颗粒 (VLPs) 会增加细胞内钙浓度，因此它们可用作增效剂来增效杀虫剂的效果。VLPs 是自我组装的病毒蛋白复合物，与昆虫病原病毒不同，它们没有遗传物质，这使得它们不具有传染性，比病毒更安全。尽管 VLPs 已被广泛用于人类健康，但我们在本研究中提出了一种有前途的策略，即基于将 VLPs 用作害虫管理中的增效剂。这将提高杀虫剂的功效，同时降低其浓度。
