Infectious Diseases and Tropical Medicine Research Center, Department of Medical Parasitology and Mycology, School of Medicine Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Infectious Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.
J Mycol Med. 2019 Apr;29(1):75-79. doi: 10.1016/j.mycmed.2018.11.004. Epub 2018 Dec 13.
Gastrointestinal basidiobolomycosis (GIB), a rare fungal infection associated with high mortality, has been reported worldwide mainly from tropical and subtropical regions of Asia, USA, and Latin America. The clinical manifestations are highly diverse and non-specific depending on the underlying disease, but fever, abdominal pain, weight loss, diarrhea, constipation and chills have been observed. There are no prominent risk factors for GIB but climatic conditions and life style are related to this infection in arid and semi-arid regions. Therefore timely diagnosis and early treatment is a challenge. Herein, we present an unusual case of gastrointestinal basidiobolomycosis in a 54-year-old male, initially misdiagnosed as colon cancer. After follow-up, no evidence of relapse and the patient was successfully cured by liposomal amphotericin B. In addition, the differential diagnosis and histopathological findings are discussed with a review of the literature.
胃肠道芽生菌病(GIB)是一种罕见的真菌感染,与高死亡率相关,已在全球范围内报告,主要来自亚洲、美国和拉丁美洲的热带和亚热带地区。临床表现高度多样化且无特异性,取决于潜在疾病,但已观察到发热、腹痛、体重减轻、腹泻、便秘和寒战。GIB 没有明显的危险因素,但气候条件和生活方式与干旱和半干旱地区的这种感染有关。因此,及时诊断和早期治疗是一个挑战。在此,我们报告了一例 54 岁男性胃肠道芽生菌病的不寻常病例,最初误诊为结肠癌。随访后,无复发证据,患者成功治愈,采用了脂质体两性霉素 B。此外,还讨论了鉴别诊断和组织病理学发现,并回顾了文献。