Alborzi clinical microbiology research center, department of pediatrics, School of medicine, Nemazi hospital, Shiraz University of medical sciences, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Infect Dis. 2024 Aug 12;24(1):816. doi: 10.1186/s12879-024-09664-8.
Zygomycosis, a severe form of fungal infection, is classified into two categories: Mucorales and Entomophthorales. Within the Entomophthorales category, Basidiobolomycosis is a rarely recognized genus that can have significant health implications. Prompt diagnosis and appropriate treatment, which includes the use of antifungal medication and surgical procedures, are vital for enhancing the prognosis of patients. The objective of this study is to investigate the response to treatment in patients hospitalized due to basidiobolomycosis.
We carried out a retrospective study, in which we analyzed data from 49 patients who were diagnosed with Entomophthorale, Zygomycosis, and Basidiobolomycosis at Namazi Hospital, Shiraz, between the years 1997 and 2019. The data included parameters such as demographic information, clinical symptoms, imaging findings, treatment methods, and patient outcomes.
Out of 49 patients, 24 children, predominantly male (83.3%), were definitively diagnosed with basidiobolomycosis. The ages of the patients ranged from 1 to 16 years, with an average of 5.75 years. The most frequently observed clinical manifestations included abdominal pain (70.8%), fever (54.2%), hematochezia (41.7%), vomiting (20.8%), and anorexia (16.7%). Half of the patients exhibited failure to thrive (FTT), while abdominal distension was present in 25% of the cases, and a palpable abdominal mass was found in 37% of the patients. The primary treatment strategy incorporated surgical interventions complemented by a comprehensive antifungal regimen. This regimen included medications such as amphotericin B, cotrimoxazole, itraconazole, potassium iodide, and voriconazole. These were mainly administered in a combination therapy pattern or as a monotherapy of amphotericin B. Twenty-two patients were discharged, while two patients died due to complications from the disease.
Our findings indicate that the prevailing treatment modalities generally involve surgical intervention supplemented by antifungal regimens, including Amphotericin B, Cotrimoxazole, Potassium Iodide, and Itraconazole.
接合菌病是一种严重的真菌感染，可分为毛霉目和外囊菌目两类。在外囊菌目中，被毛孢菌病是一种很少被认识的真菌病属，可能对健康有重大影响。及时诊断和适当的治疗，包括使用抗真菌药物和手术，对于改善患者的预后至关重要。本研究的目的是探讨因被毛孢菌病住院的患者的治疗反应。
我们进行了一项回顾性研究，分析了 1997 年至 2019 年期间在设拉子的纳马齐医院被诊断为接合菌病、外囊菌病和被毛孢菌病的 49 名患者的数据。数据包括人口统计学信息、临床症状、影像学发现、治疗方法和患者结局等参数。
49 名患者中，有 24 名儿童（主要为男性，占 83.3%）被明确诊断为被毛孢菌病。患者年龄 1 至 16 岁，平均年龄 5.75 岁。最常见的临床表现包括腹痛（70.8%）、发热（54.2%）、血便（41.7%）、呕吐（20.8%）和食欲不振（16.7%）。一半的患者表现为生长迟缓（FTT），25%的患者有腹部膨隆，37%的患者可触及腹部肿块。主要的治疗策略是手术干预辅以全面的抗真菌治疗方案。该方案包括两性霉素 B、复方磺胺甲噁唑、伊曲康唑、碘化钾和伏立康唑等药物。这些药物主要以联合治疗或两性霉素 B 单药治疗的形式使用。22 名患者出院，2 名患者因疾病并发症死亡。
我们的研究结果表明，目前主要的治疗方法通常是手术干预辅以抗真菌治疗方案，包括两性霉素 B、复方磺胺甲噁唑、碘化钾和伊曲康唑。
