EGR 介导的 STIM 表达和功能的调控。
EGR-mediated control of STIM expression and function.
机构信息
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA.
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA; Department of Medical Genetics & Molecular Biochemistry, Temple University School of Medicine, Philadelphia, PA, 19140, USA.
出版信息
Cell Calcium. 2019 Jan;77:58-67. doi: 10.1016/j.ceca.2018.12.003. Epub 2018 Dec 6.
Ca is a ubiquitous, dynamic and pluripotent second messenger with highly context-dependent roles in complex cellular processes such as differentiation, proliferation, and cell death. These Ca signals are generated by Ca-permeable channels located on the plasma membrane (PM) and endoplasmic reticulum (ER) and shaped by PM- and ER-localized pumps and transporters. Differences in the expression of these Ca homeostasis proteins contribute to cell and context-dependent differences in the spatiotemporal organization of Ca signals and, ultimately, cell fate. This review focuses on the Early Growth Response (EGR) family of zinc finger transcription factors and their role in the transcriptional regulation of Stromal Interaction Molecule (STIM1), a critical regulator of Ca entry in both excitable and non-excitable cells.
钙是一种普遍存在的、动态的、多能的第二信使，在分化、增殖和细胞死亡等复杂细胞过程中具有高度依赖上下文的作用。这些钙信号是由位于质膜 (PM) 和内质网 (ER) 上的钙通透通道产生的，并由 PM 和 ER 定位的泵和转运体形成。这些钙稳态蛋白的表达差异导致钙信号的时空组织以及最终细胞命运在细胞和环境上存在差异。这篇综述重点介绍了早期生长反应 (EGR) 家族的锌指转录因子及其在基质相互作用分子 (STIM1) 的转录调控中的作用，STIM1 是兴奋和非兴奋细胞中钙内流的关键调节剂。
Zotero 插件