International University-Vietnam National University HCMC, Department of Biomedical Engineering, Ho, Vietnam.
University of Medicine and Pharmacy, Department of Pharmacognosy, Ho Chi Minh City, Vietnam.
J Biomed Opt. 2018 Dec;23(12):1-8. doi: 10.1117/1.JBO.23.12.125003.
Skin cancer is one of the most common cancers, including melanoma and nonmelanoma cancer. Melanoma can be easily detected by the observation of abnormal moles, but nonmelanoma signs and symptoms are not apparent in the early stages. We use the Stokes-Mueller matrix decomposition method to detect nonmelanoma at the early stage by decomposing the characteristics of polarized light interacting with normal and cancerous tissues. With this decomposition method, we extract nine optical parameters from biological tissues, namely the LB orientation angle (α), the LB phase retardance (β), the CB optical rotation angle (γ), the LD orientation angle (θd), the linear dichroism (D), the circular dichroism (R), the degrees of linear depolarization (e1 and e2), the degree of circular depolarization (e3), and the depolarization index (Δ). The healthy skin and the induced nonmelanoma skin cancer of mice are analyzed and compared based on their optical parameters. We find distinctive ranges of values for normal skin tissue and nonmelanoma skin cancer, in which β and D in cancerous tissue are larger and nonmelanoma skin becomes less depolarized. This research creates an innovative solid foundation for the diagnosis of skin cancer in the future.
皮肤癌是最常见的癌症之一，包括黑色素瘤和非黑色素瘤癌症。黑色素瘤可以通过观察异常痣来轻易检测到，但非黑色素瘤在早期阶段的迹象和症状并不明显。我们使用 Stokes-Mueller 矩阵分解方法，通过分解与正常和癌变组织相互作用的偏振光的特性来检测早期的非黑色素瘤。使用这种分解方法，我们从生物组织中提取了九个光学参数，即 LB 取向角 (α)、LB 相位延迟 (β)、CB 光旋转角 (γ)、LD 取向角 (θd)、线性二色性 (D)、圆二色性 (R)、线偏振度 (e1 和 e2)、圆偏振度 (e3) 和去偏振指数 (Δ)。基于这些光学参数，我们对健康皮肤和诱导的小鼠非黑色素瘤皮肤癌进行了分析和比较。我们发现正常皮肤组织和非黑色素瘤皮肤癌之间有明显的数值范围，其中癌变组织中的β和 D 较大，而非黑色素瘤皮肤的去偏振程度较低。这项研究为未来皮肤癌的诊断奠定了创新的坚实基础。
