University of British Columbia, School of Biomedical Engineering, Vancouver, Canada.
University of British Columbia and Vancouver Coastal Health Research Institute, Department of Dermat, Canada.
J Biomed Opt. 2018 Dec;23(12):1-7. doi: 10.1117/1.JBO.23.12.125004.
Determining the optical polarization properties of a skin lesion is a proposed method to differentiate melanoma from other skin lesions. We developed an in vivo Stokes polarimetry probe that fires a laser of known polarization at the skin and measures the Stokes parameters of the backscattered light in one shot. From these measured Stokes parameters, we can calculate the degree of polarization (DOP). Through testing on rough skin phantoms, a correlation between backscattered DOP and skin roughness was identified for both linear and circular input polarization, the latter of which was found to be more useful. In a pilot clinical trial of 69 skin lesions in vivo, it was found that the mean DOP for melanoma (linear input on melanoma: 0.46 ± 0.09) was greater than that of other lesions (linear input on all other lesions: 0.28 ± 0.01). This separation is greater for circular polarized input light, and it is likely that circular polarized light's greater sensitivity to surface roughness contributes to this result. In addition, all skin lesions demonstrated a stronger depolarizing effect on circular polarized light than linear polarized light. We have identified DOP as a potentially useful measurement to identify melanoma among other types of skin lesions.
确定皮肤病变的光学偏振特性是一种将黑色素瘤与其他皮肤病变区分开来的方法。我们开发了一种体内 Stokes 偏振探测仪，它可以向皮肤发射已知偏振的激光，并在一次拍摄中测量背散射光的 Stokes 参数。从这些测量的 Stokes 参数中，我们可以计算出偏振度 (DOP)。通过对粗糙皮肤模型的测试，发现背散射 DOP 与皮肤粗糙度之间存在线性和圆偏振输入的相关性，后者被发现更有用。在一项针对 69 例体内皮肤病变的初步临床试验中，发现黑色素瘤的平均 DOP（黑色素瘤的线性输入：0.46±0.09）大于其他病变（所有其他病变的线性输入：0.28±0.01）。对于圆偏振输入光，这种分离更大，这可能是由于圆偏振光对表面粗糙度更敏感导致的结果。此外，所有皮肤病变对圆偏振光的去偏振效应都比线偏振光强。我们已经确定 DOP 是一种识别黑色素瘤和其他类型皮肤病变的有用测量方法。
