卡波西肉瘤相关疱疹病毒合并感染，一种与HPV相关宫颈癌发生的新辅助因素？
KSHV co-infection, a new co-factor for HPV-related cervical carcinogenesis?
作者信息
Dai Lu, Zhao Mengmeng, Jiang Wei, Lin Zhen, Del Valle Luis, Qin Zhiqiang
机构信息
Department of Genetics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center 1700 Tulane Ave, New Orleans, LA 70112, USA.
Department of Pediatrics, Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, School of Medicine, Tongji University Shanghai 200120, China.
出版信息
Am J Cancer Res. 2018 Nov 1;8(11):2176-2184. eCollection 2018.
High-risk human papillomavirus (HPV) infection is the etiological agent of cervical cancer and some other cancers. Kaposi sarcoma-associated herpesvirus (KSHV) represents a principal causative agent of several human cancers arising in those immunocompromised patients. In fact, KSHV DNA has been detected in the female genital tract, and this virus may share some transmission routes with HPV, although the detection rate of KSHV in cervical samples is very low and the KSHV/HPV co-infection is seldom reported. Currently, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasias. In this article, we have summarized the recent finding from clinic and bench indicating KSHV co-infection may represent a co-factor for the development of HPV-related carcinogenesis.
高危型人乳头瘤病毒（HPV）感染是宫颈癌和其他一些癌症的病原体。卡波西肉瘤相关疱疹病毒（KSHV）是免疫功能低下患者中几种人类癌症的主要致病因子。事实上，已在女性生殖道中检测到KSHV DNA，并且这种病毒可能与HPV有一些共同的传播途径，尽管宫颈样本中KSHV的检出率非常低，且KSHV/HPV合并感染鲜有报道。目前，KSHV合并感染在HPV相关肿瘤发生中的作用仍不清楚。在本文中，我们总结了临床和实验室的最新发现，表明KSHV合并感染可能是HPV相关致癌作用发生的一个辅助因素。
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