脑脊液总tau蛋白水平与海马体新奇性相关，与海马体体积无关。
CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume.
作者信息
Düzel Emrah, Berron David, Schütze Hartmut, Cardenas-Blanco Arturo, Metzger Coraline, Betts Matthew, Ziegler Gabriel, Chen Yi, Dobisch Laura, Bittner Daniel, Glanz Wenzel, Reuter Martin, Spottke Annika, Rudolph Janna, Brosseron Frederic, Buerger Katharina, Janowitz Daniel, Fliessbach Klaus, Heneka Michael, Laske Christoph, Buchmann Martina, Nestor Peter, Peters Oliver, Diesing Dominik, Li Siyao, Priller Josef, Spruth Eike Jakob, Altenstein Slawek, Ramirez Alfredo, Schneider Anja, Kofler Barbara, Speck Oliver, Teipel Stefan, Kilimann Ingo, Dyrba Martin, Wiltfang Jens, Bartels Claudia, Wolfsgruber Steffen, Wagner Michael, Jessen Frank
机构信息
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
出版信息
Alzheimers Dement (Amst). 2018 Nov 2;10:782-790. doi: 10.1016/j.dadm.2018.10.003. eCollection 2018.
INTRODUCTION
We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.
METHODS
We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images.
RESULTS
Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ levels and novelty responses.
DISCUSSION
Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.
引言
我们研究了老年痴呆前期患者脑脊液（CSF）中阿尔茨海默病生物标志物、神经新奇反应与脑容量之间的关联。
方法
我们对多中心观察性研究“德国神经退行性疾病中心纵向认知障碍与痴呆研究（DELCODE）”进行了横断面分析。76名参与者完成了任务功能磁共振成像检查并提供了脑脊液样本（40名认知未受损者、21名有主观认知衰退者和15名轻度认知障碍者）。我们评估了脑脊液生物标志物与全脑功能磁共振成像对场景图像的新奇反应之间的相关性。
结果
总tau蛋白水平与右侧杏仁核和右侧海马体的新奇反应呈特异性负相关。中介分析表明，没有证据表明这些关联依赖于海马体/杏仁核的体积。未发现磷酸化tau蛋白或淀粉样β蛋白水平与新奇反应之间存在关联。
讨论
我们的数据表明，脑脊液中总tau蛋白水平与新奇处理过程中特定解剖部位的减少有关，而萎缩并不能完全解释这种现象。
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