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颞下颌关节组织工程

Tissue Engineering for the Temporomandibular Joint.

机构信息

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA.

Department of Orthodontics, College of Dentistry and Dental Clinics, University of Iowa, Iowa City, Iowa, 52242, USA.

出版信息

Adv Healthc Mater. 2019 Jan;8(2):e1801236. doi: 10.1002/adhm.201801236. Epub 2018 Dec 17.

DOI:10.1002/adhm.201801236
PMID:30556348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075314/
Abstract

Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Tissue engineering approaches for the temporomandibular joint are a promising alternative to the limited clinical treatment options. However, tissue engineering is still a developing field and only in its formative years for the temporomandibular joint. This review outlines the anatomical and physiological characteristics of the temporomandibular joint, clinical management of temporomandibular joint disorder, and current perspectives in the tissue engineering approach for the temporomandibular joint disorder. The tissue engineering perspectives have been categorized according to the primary structures of the temporomandibular joint: the disc, the mandibular condyle, and the glenoid fossa. In each section, contemporary approaches in cellularization, growth factor selection, and scaffold fabrication strategies are reviewed in detail along with their achievements and challenges.

摘要

组织工程为经常困扰患者的颞下颌关节紊乱提供了新的治疗方法。该区域的损伤或疾病会对咀嚼功能和言语产生不利影响，降低患者的生活质量。患有严重颞下颌关节紊乱的患者对有效治疗方法的需求很高，因为手术选择仅限于去除受损组织或用假体完全替换关节。组织工程方法是治疗颞下颌关节的一种很有前途的替代方法，可替代有限的临床治疗选择。然而，组织工程仍然是一个发展中的领域，在颞下颌关节方面还处于起步阶段。本文概述了颞下颌关节的解剖学和生理学特征、颞下颌关节紊乱的临床管理以及颞下颌关节紊乱的组织工程方法的最新进展。根据颞下颌关节的主要结构（关节盘、下颌骨髁突和关节窝）对组织工程观点进行了分类。在每个部分中，详细回顾了细胞化、生长因子选择和支架制造策略的当代方法及其成就和挑战。

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