Milodowski Emily Jayne, Amengual-Batle Pablo, Beltran Elsa, Gutierrez-Quintana Rodrigo, De Decker Steven
Department of Veterinary Clinical Science and Services, Royal Veterinary College, University of London, Hatfield, England, United Kingdom.
School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
J Vet Intern Med. 2019 Mar;33(2):735-742. doi: 10.1111/jvim.15373. Epub 2018 Dec 17.
Little is known about the spectrum of underlying disorders in dogs with unilateral masticatory muscle (MM) atrophy.
To evaluate the clinical presentation, magnetic resonance imaging (MRI) findings, and outcome of dogs with unilateral MM atrophy.
Sixty-three client-owned dogs.
The medical database was retrospectively reviewed for dogs that underwent MRI for evaluation of unilateral MM atrophy. Imaging studies were reviewed and follow-up information was obtained from telephone interviews.
Presumptive trigeminal nerve sheath tumor (pTNST) was diagnosed in 30 dogs (47.6%); survival time varied from 1 day to 21 months (median, 5 months). Other extra-axial mass lesions were observed in 13 dogs (20.6%); survival time varied from 6 days to 25 months (median, 2.5 months). In 18 dogs (28.6%), no abnormalities were observed on MRI; neurological signs only progressed in 1 dog. Diagnosis had a significant influence on the type of neurological abnormalities, with additional neurological deficits observed in most dogs with pTNST and in all dogs with other extra-axial mass lesions. Diagnosis had a significant effect on euthanasia at the time of diagnosis and likelihood of neurological deterioration. Dogs with mass lesions were more likely to be euthanized or experience neurological deterioration, whereas these outcomes occurred less often in dogs in which no causative lesion could be identified.
Trigeminal nerve sheath tumors should not be considered the only cause of unilateral MM atrophy. Our results illustrate the importance of performing a neurological examination and MRI when evaluating dogs with unilateral MM atrophy.
关于单侧咀嚼肌萎缩犬潜在疾病谱的了解甚少。
评估单侧咀嚼肌萎缩犬的临床表现、磁共振成像（MRI）结果及预后。
63只客户拥有的犬。
回顾医学数据库中因评估单侧咀嚼肌萎缩而接受MRI检查的犬。对影像学研究进行回顾，并通过电话访谈获取随访信息。
30只犬（47.6%）被诊断为疑似三叉神经鞘瘤（pTNST）；生存时间从1天到21个月不等（中位数为5个月）。13只犬（20.6%）观察到其他轴外肿块病变；生存时间从6天到25个月不等（中位数为2.5个月）。18只犬（28.6%）MRI未观察到异常；仅1只犬神经症状进展。诊断对神经异常类型有显著影响，大多数pTNST犬和所有其他轴外肿块病变犬出现额外神经功能缺损。诊断对诊断时的安乐死及神经功能恶化可能性有显著影响。有肿块病变的犬更可能被安乐死或出现神经功能恶化，而在未发现病因性病变的犬中这些情况较少发生。
不应将三叉神经鞘瘤视为单侧咀嚼肌萎缩的唯一原因。我们的结果表明在评估单侧咀嚼肌萎缩犬时进行神经学检查和MRI的重要性。
