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暴饮对发育中大脑的影响。

Effects of Binge Drinking on the Developing Brain.

作者信息

Jones Scott A, Lueras Jordan M, Nagel Bonnie J

机构信息

Scott A. Jones and Jordan M. Lueras are graduate students in the Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon. Bonnie J. Nagel, Ph.D., is an associate professor in the Departments of Behavioral Neuroscience and Psychiatry, Oregon Health & Science University, Portland, Oregon.

出版信息

Alcohol Res. 2018;39(1):87-96.

PMID:30557151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6104956/
Abstract

Binge drinking is a pattern of alcohol drinking that raises a person's blood alcohol concentration to at least .08%, which amounts to consuming five alcoholic drinks for men and four alcoholic drinks for women in about 2 hours. It is the most common form of alcohol misuse in adolescents and young adults. Heavy drinking includes the same criterion as binge drinking, but with higher frequency (i.e., 5 or more days in the past 30 days). Although binge drinking or heavy drinking alone is insufficient to meet the criteria for an alcohol use disorder (AUD) diagnosis, there are neurobiological changes, as well as an increased risk of developing an AUD later in life, associated with this form of alcohol misuse. This review describes the recent neuroimaging findings in binge drinking and heavy-drinking adolescents and young adults, a developmental period during which significant neuromaturation occurs.

摘要

暴饮是一种饮酒模式,会使一个人的血液酒精浓度至少升至0.08%,这相当于男性在约两小时内饮用五杯酒精饮料,女性饮用四杯酒精饮料。它是青少年和青年中最常见的酒精滥用形式。重度饮酒包括与暴饮相同的标准,但频率更高(即过去30天内有5天或更多天饮酒)。虽然仅暴饮或重度饮酒不足以满足酒精使用障碍(AUD)的诊断标准,但这种形式的酒精滥用会导致神经生物学变化,以及日后患酒精使用障碍的风险增加。这篇综述描述了近期针对暴饮和重度饮酒的青少年及青年的神经影像学研究结果,这是一个发生显著神经成熟的发育阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74aa/6104956/a9d29acd3351/arcr-39-1-e1_a10f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74aa/6104956/a9d29acd3351/arcr-39-1-e1_a10f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74aa/6104956/a9d29acd3351/arcr-39-1-e1_a10f1.jpg

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A Preliminary Prospective Study of an Escalation in 'Maximum Daily Drinks', Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers.
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Repeated cycles of binge-like ethanol consumption and abstinence alter neuropeptide mRNA in prefrontal and insular cortex, amygdala, and lateral hypothalamus of male and female C57BL/6J mice.雄性和雌性C57BL/6J小鼠反复进行类似暴饮暴食的乙醇摄入和戒酒循环,会改变前额叶和岛叶皮质、杏仁核以及下丘脑外侧的神经肽mRNA。
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