Ohta Shigeo
Nihon Rinsho. 2016 Sep;74(9):1456-1460.
Mitochondrion is an organelle that plays major roles in energy metabolism, which is regu- lated by three mitochondrial products of the Sirtuin genes. The energy metabolism accom- panies the sub-production of reactive oxygen species, which may damage mitochondrion itself, its own DNA and various cell components by oxidation, but which function as physiologi- cally important signal molecules. Damaged mitochondria are removed by mitophagy to main- tain the quality of mitochondria. Mitochondrion plays essential roles in innate immunity. Mitochondrion exerts a multiple function to be involved in the aging process.
线粒体是一种在能量代谢中起主要作用的细胞器，其能量代谢由沉默调节蛋白基因的三种线粒体产物调控。能量代谢伴随着活性氧的次级产生，活性氧可通过氧化作用损伤线粒体本身、其自身的DNA和各种细胞成分，但它也作为生理上重要的信号分子发挥作用。受损的线粒体通过线粒体自噬被清除，以维持线粒体的质量。线粒体在固有免疫中发挥着重要作用。线粒体发挥多种功能参与衰老过程。
