Nakanuma Y, Yoshida K
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Acta Pathol Jpn. 1988 Jul;38(7):853-60. doi: 10.1111/j.1440-1827.1988.tb02357.x.
Expression of beta 2-microglobulin, a reliable marker of HLA Class I, on the interlobular bile ducts (bile ducts) was surveyed using an immunoperoxidase method in paraffin sections of specimens from patients with a variety of hepatobiliary diseases. Normal bile ducts showed negativity or weak cytoplasmic positivity in normal as well as diseased livers. On the other hand, abnormal bile ducts showing degenerative or proliferative changes in primary biliary cirrhosis and graft-versus-host disease revealed enhanced expression of this protein, suggesting that these damaged bile ducts might be more susceptible to T cell-mediated immune attack in these immunologic diseases. However, enhanced expression of this protein was also similarly found on abnormal bile ducts in several nonimmunologic biliary diseases including extrahepatic biliary obstruction. Enhanced expression of this protein on the interlobular bile ducts may therefore be an epiphenomenon secondary to different primary pathologic events in the biliary tree, such as immunologic and nonimmunologic processes.
采用免疫过氧化物酶法，在石蜡切片上对各种肝胆疾病患者标本进行研究，以检测叶间胆管（胆管）上β2微球蛋白（一种可靠的HLA I类标志物）的表达情况。正常胆管在正常肝脏以及患病肝脏中均呈阴性或细胞质弱阳性。另一方面，在原发性胆汁性肝硬化和移植物抗宿主病中出现退行性或增殖性变化的异常胆管，显示出该蛋白表达增强，这表明在这些免疫性疾病中，这些受损胆管可能更容易受到T细胞介导的免疫攻击。然而，在包括肝外胆管梗阻在内的几种非免疫性胆管疾病的异常胆管中，也同样发现了该蛋白表达增强。因此，叶间胆管上该蛋白表达增强可能是胆管树中不同原发性病理事件（如免疫和非免疫过程）继发的一种附带现象。
