Research Unit for General Practice.
Department of Public Health.
Br J Gen Pract. 2019 Mar;69(680):e182-e189. doi: 10.3399/bjgp18X700733. Epub 2018 Dec 17.
Depression is a common mental illness worldwide. The offspring of a mother with depression has higher risk of developing mental and physical illness.
This study aimed to investigate the association between the timing of maternal depression and the use of primary health care for the offspring.
A population-based birth cohort study in Danish primary care using Danish national registers.
All Danish children born between 1 January 2000 and 31 December 2013 ( = 869 140 children) were included in the study. The primary outcome was number and type of annual contacts with the GP. The secondary outcome was specific services used by the GP to assess inflammatory and infectious disease in the children. Exposure was maternal depression of four categories: non-depressed, recent, previous, and past depression. The association was expressed as adjusted incidence rate ratios (IRR) with 95% confidence intervals (CI).
Maternal depression was associated with a higher use of primary health care for all three categories of depression. The strongest association was found for children of a mother with recent depression; they had 16% more contacts than children of a non-depressed mother (adjusted IRR = 1.16, 95% CI = 1.15 to 1.17), and 19-24% more positive infectious-related tests were found in this group.
Exposure to maternal depression was associated with a significantly higher use of primary health care for the offspring for all exposure categories. These findings reveal that healthcare use is higher for the offspring exposed to maternal depression, even several years after expected remission. The higher ratio of positive tests indicates that exposed children are ill with infectious disease more often.
抑郁症是一种常见的精神疾病,全球范围内都有发生。患有抑郁症的母亲的后代患精神和身体疾病的风险更高。
本研究旨在探讨母亲抑郁发病时间与后代利用初级保健的关系。
这是一项基于人群的丹麦初级保健中的出生队列研究,使用丹麦国家登记处。
本研究纳入了 2000 年 1 月 1 日至 2013 年 12 月 31 日期间出生的所有丹麦儿童(=869140 名儿童)。主要结局指标是 GP 年度就诊次数和类型。次要结局指标是 GP 用于评估儿童炎症和传染性疾病的特定服务。暴露因素为母亲的四种抑郁类别:未患抑郁症、近期、既往和过去抑郁症。关联以调整后的发病率比值比(IRR)和 95%置信区间(CI)表示。
母亲抑郁与所有三种抑郁类别儿童对初级保健的利用呈正相关。与非抑郁母亲的孩子相比,近期患抑郁症母亲的孩子就诊次数最多,增加了 16%(调整后的 IRR=1.16,95%CI=1.15 至 1.17),该组中发现更多的阳性感染相关检查。
暴露于母亲抑郁与后代利用初级保健的显著增加相关,所有暴露类别均如此。这些发现表明,即使在预期缓解多年后,暴露于母亲抑郁的后代对医疗保健的使用也更高。阳性检查的比例更高表明,暴露的儿童更常患有传染性疾病。