Research Unit for General Practice, and Department of Public Health, Aarhus University.
Department of Public Health, Aarhus University.
Br J Gen Pract. 2021 Jan 28;71(703):e105-e112. doi: 10.3399/bjgp20X714173. Print 2021.
Maternal depression has been linked to adverse outcomes in the offspring. Existing literature is mainly based on parental reports, which can be an unreliable source when the parent has depression.
To explore if maternal depression was associated with daily health complaints and low self-assessed health (SAH) in the offspring.
Participants were 45 727 children from the Danish National Birth Cohort recruited between 1996 and 2002. At 11-year follow-up, mothers and their children were invited to complete a questionnaire. Maternal depression was categorised into: no depression, first-time treatment, continued treatment, post-treatment, and relapse.
Binomial regression was used to estimate the adjusted prevalence proportion ratio (aPPR) of frequent health complaints and low SAH in children of mothers with depression compared to children of mothers without depression.
The prevalence of any daily health complaint was 11.4%, daily somatic complaints 4.1%, daily mental complaints 8.9%, both daily mental and somatic complaints 1.5%, and low SAH 5.3%. Children of mothers with depression (any category) were more likely to report a daily health complaint: first-time treatment aPPR 1.35 (95% confidence interval [CI] = 0.96 to 1.85), continued treatment aPPR 1.59 (95% CI = 1.37 to 1.85), post-treatment aPPR 1.30 (95% CI = 1.20 to 1.41), and relapse aPPR 1.56 (95% CI = 1.35 to 1.79). Children of mothers with depression were also more likely to report low SAH: first-time treatment aPPR 1.58 (95% CI = 0.99 to 2.54), continued treatment aPPR 1.86 (95% CI = 1.51 to 2.28), post-treatment aPPR 1.34 (95% CI = 1.19 to 1.50), and relapse aPPR 1.56 (95% CI = 1.26 to 1.93). Girls had a higher prevalence of mental and somatic health complaints and more often reported low SAH compared to boys.
Treatment of maternal depression was associated with higher prevalence of daily health complaints and low SAH in the offspring at age 11 years. The association was strongest for children of mothers with continued depression or relapse.
母亲的抑郁与后代的不良后果有关。现有文献主要基于父母报告，而当父母患有抑郁症时，这可能是一个不可靠的来源。
探讨母亲的抑郁是否与后代的日常健康问题和低自我评估健康（SAH）有关。
参与者是 1996 年至 2002 年期间招募的丹麦全国出生队列的 45727 名儿童。在 11 年的随访中，邀请母亲及其子女完成一份问卷。将母亲的抑郁分为：无抑郁、首次治疗、持续治疗、治疗后和复发。
使用二项式回归来估计与无抑郁母亲的子女相比，患有抑郁的母亲的子女中频繁出现健康问题和低 SAH 的调整后患病率比（aPPR）。
任何日常健康问题的患病率为 11.4%，日常躯体问题为 4.1%，日常精神问题为 8.9%，同时存在日常精神和躯体问题为 1.5%，低 SAH 为 5.3%。患有抑郁症的母亲（任何类别）的子女更有可能报告日常健康问题：首次治疗 aPPR 为 1.35（95%置信区间[CI] = 0.96 至 1.85），持续治疗 aPPR 为 1.59（95% CI = 1.37 至 1.85），治疗后 aPPR 为 1.30（95% CI = 1.20 至 1.41），复发 aPPR 为 1.56（95% CI = 1.35 至 1.79）。患有抑郁症的母亲的子女也更有可能报告低 SAH：首次治疗 aPPR 为 1.58（95% CI = 0.99 至 2.54），持续治疗 aPPR 为 1.86（95% CI = 1.51 至 2.28），治疗后 aPPR 为 1.34（95% CI = 1.19 至 1.50），复发 aPPR 为 1.56（95% CI = 1.26 至 1.93）。与男孩相比，女孩的精神和躯体健康问题的患病率更高，且更常报告低 SAH。
母亲抑郁的治疗与 11 岁儿童日常健康问题和低 SAH 的发生率较高有关。对于持续患有抑郁症或复发的母亲的子女，这种关联最强。
