Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
State Key Laboratory of Electronic Thin films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, People's Republic of China.
Nat Commun. 2018 Dec 17;9(1):5349. doi: 10.1038/s41467-018-07764-z.
In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompatible nanogenerator that is attached on the surface of stomach. It generates biphasic electric pulses in responsive to the peristalsis of stomach. The electric signals generated by this device can stimulate the vagal afferent fibers to reduce food intake and achieve weight control. This strategy is successfully demonstrated on rat models. Within 100 days, the average body weight is controlled at 350 g, 38% less than the control groups. This work correlates nerve stimulation with targeted organ functionality through a smart, self-responsive system, and demonstrated highly effective weight control. This work also provides a concept in therapeutic technology using artificial nerve signal generated from coordinated body activities.
体内迷走神经刺激在调节食物摄入以治疗肥胖方面具有巨大的潜力。在这里，我们提出了一种植入式迷走神经刺激系统，它无需电池，并且可以自发响应胃部运动。该迷走神经刺激系统包括一个附着在胃表面的柔性和生物相容性的纳米发电机。它会响应胃的蠕动产生双相电脉冲。该设备产生的电信号可以刺激迷走传入纤维，减少食物摄入，达到控制体重的目的。该策略在大鼠模型中得到了成功验证。在 100 天内，平均体重控制在 350 克，比对照组低 38%。这项工作通过智能、自响应系统将神经刺激与靶向器官功能相关联，并展示了非常有效的体重控制效果。这项工作还为使用源自协调身体活动的人工神经信号的治疗技术提供了一个概念。
Nat Commun. 2018-12-17
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