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肥胖治疗的新兴纳米技术策略

Emerging Nanotechnology Strategies for Obesity Therapy.

作者信息

Chang Weili, Meng Zhaoxu, Zhao Yuezhu, Qi Yake, Li Zhou, Lian He

机构信息

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.

School of Medical Instrumentation, Shenyang Pharmaceutical University, Shenyang, 110016, China.

出版信息

Adv Sci (Weinh). 2025 Aug;12(32):e01813. doi: 10.1002/advs.202501813. Epub 2025 Jul 14.

Abstract

With the rising prevalence of obesity worldwide, the condition and its associated complications have become a significant public health challenge. The emergence of nanotechnology presents new opportunities for obesity treatment by enabling the design and manipulation of materials at the nanoscale to exhibit unique physicochemical properties, targeted delivery capabilities, and multifunctional therapeutic effects. This review systematically explores recent advances in nanotechnology-based strategies for obesity management, focusing on the pathological characteristics of obesity, the types of nanomaterials for the treatment, and the therapeutic strategies provided by nanotechnology. Furthermore, the review critically examines translational challenges while proposing innovative solutions. This work aims to foster the effective application and rapid advancement of nanotechnology in addressing obesity.

摘要

随着全球肥胖患病率的不断上升,肥胖症及其相关并发症已成为一项重大的公共卫生挑战。纳米技术的出现为肥胖症治疗带来了新机遇,它能够在纳米尺度上设计和操控材料,使其展现出独特的物理化学性质、靶向递送能力及多功能治疗效果。本综述系统地探讨了基于纳米技术的肥胖症管理策略的最新进展,重点关注肥胖症的病理特征、用于治疗的纳米材料类型以及纳米技术提供的治疗策略。此外,本综述批判性地审视了转化过程中面临的挑战,并提出了创新性解决方案。这项工作旨在促进纳米技术在解决肥胖问题方面的有效应用和快速发展。

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