Chen Xuemei, Chen Xin, Chen Yan, Xu Manman, Yu Tingting, Li Junrong
Department of Neurology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, China.
Front Hum Neurosci. 2018 Nov 28;12:471. doi: 10.3389/fnhum.2018.00471. eCollection 2018.
: The exact relationship between white matter hyperintensity (WMH) and intracerebral hemorrhage (ICH) after ICH remains unclear. In this retrospective study, we investigated whether patients with ICH had more severe WMH progression. : A total of 2,951 patients aged ≥40 years with ICH who received brain computed tomography (CT) imaging within 12 h of ICH symptom onset were screened. Ninety patients with two fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) assessments, including 36 patients with Lobar ICH, 40 with basal ganglia region ICH and 14 with ICH at other sites, were included in the final study. We selected 90 age- and gender-matched healthy individuals with two MRI scans as the control group. The WMH volumes at baseline and follow-up were assessed using the FLAIR image by MRICRON and ITK-SNAP software, while the hematoma volumes were calculated based on the CT images using ITK-SNAP software. : The annual progression rate of WMH was significantly higher in the ICH group compared with the control group ( < 0.05). Furthermore, WMH progression was associated with the ICH volume. The largest ICH volume (>30 mL) was associated with the highest annual progression rate of WMH ( < 0.05). In contrast, no trend toward an association between ICH location and the annual progression rate of WMH was observed ( > 0.05). : Our results showed that ICH patients had more severe WMH progression and that larger ICH volume was related to greater progression of WMH after ICH. These results could provide important prognostic information about patients with ICH.
脑出血（ICH）后白质高信号（WMH）与脑出血的确切关系尚不清楚。在这项回顾性研究中，我们调查了脑出血患者是否有更严重的WMH进展情况。
共筛选了2951例年龄≥40岁、在脑出血症状发作后12小时内接受脑部计算机断层扫描（CT）成像的脑出血患者。最终研究纳入了90例接受两次液体衰减反转恢复（FLAIR）磁共振成像（MRI）评估的患者，其中包括36例脑叶脑出血患者、40例基底节区脑出血患者和14例其他部位脑出血患者。我们选择90例年龄和性别匹配、接受两次MRI扫描的健康个体作为对照组。使用MRICRON和ITK-SNAP软件通过FLAIR图像评估基线和随访时的WMH体积，而使用ITK-SNAP软件根据CT图像计算血肿体积。
与对照组相比，脑出血组WMH的年进展率显著更高（<0.05）。此外，WMH进展与脑出血体积相关。最大脑出血体积（>30 mL）与WMH的最高年进展率相关（<0.05）。相比之下，未观察到脑出血位置与WMH年进展率之间存在关联趋势（>0.05）。
我们的结果表明，脑出血患者有更严重的WMH进展，且脑出血体积越大与脑出血后WMH的更大进展相关。这些结果可为脑出血患者提供重要的预后信息。
