粉末冶金钛-镁金属-金属复合材料有助于骨传导和骨整合，用于骨科应用。
Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application.
作者信息
Ouyang Sihui, Huang Qianli, Liu Yong, Ouyang Zhengxiao, Liang Luxin
机构信息
State Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, PR China.
Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
出版信息
Bioact Mater. 2018 Dec 11;4(1):37-42. doi: 10.1016/j.bioactmat.2018.12.001. eCollection 2019 Mar.
In this work, Ti-Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti-Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and Ti-Mg MMCs implants were embedded into the femur condyles. Results showed that Ti-Mg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around Ti-Mg implants than around Ti implants, indicating that more active new-bone formed around Ti-Mg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around Ti-Mg implants than that around Ti implants.
在本研究中，通过放电等离子体烧结（SPS）成功制备了钛-镁金属-金属复合材料（MMCs）。在体外，研究了SaOS-2细胞对钛-镁金属-金属复合材料（MMCs）的增殖和分化反应。在体内，采用股骨髁缺损大鼠模型，将钛-镁MMCs植入物植入股骨髁。结果表明，与纯钛相比，钛-镁MMCs对SaOS-2细胞表现出更强的细胞相容性。显微计算机断层扫描（Micro-CT）结果显示，钛-镁植入物周围的骨小梁体积明显比钛植入物周围丰富，表明钛-镁MMCs植入物周围形成了更活跃的新骨。苏木精-伊红（H&E）染色分析显示，钛-镁植入物周围的骨整合明显优于钛植入物周围。
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