衰老过程中的神经肌肉接头维持与修复
NMJ maintenance and repair in aging.
作者信息
Taetzsch Thomas, Valdez Gregorio
机构信息
Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA.
Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.
出版信息
Curr Opin Physiol. 2018 Aug;4:57-64. doi: 10.1016/j.cophys.2018.05.007. Epub 2018 Jun 11.
Abstract
As the final output of the somatic nervous system, the neuromuscular junction (NMJ) is essential for all voluntary movements. The NMJ is also necessary for connected cells to function and survive. Because of this central role, much effort has been devoted to understanding the effects of aging, diseases, and injuries on the NMJ. These efforts have revealed a close relationship between aberrant changes at NMJs and its three cellular components - the presynaptic site on motor axons, the postsynaptic region on muscle fibers and perisynaptic Schwann cells. Here, we review the morphological and molecular changes associated with aging NMJs in rodents and humans. We also provide an overview of factors with potential roles in maintaining and repairing adult and aged NMJs.
摘要
作为躯体神经系统的最终输出部位，神经肌肉接头（NMJ）对于所有自主运动至关重要。神经肌肉接头对于相连细胞的功能和存活也是必需的。由于其核心作用，人们投入了大量精力来了解衰老、疾病和损伤对神经肌肉接头的影响。这些努力揭示了神经肌肉接头处的异常变化与其三个细胞成分——运动轴突上的突触前位点、肌纤维上的突触后区域和突触周围施万细胞之间的密切关系。在这里，我们综述了与啮齿动物和人类衰老神经肌肉接头相关的形态学和分子变化。我们还概述了在维持和修复成年及衰老神经肌肉接头中可能发挥作用的因素。
相似文献
1
NMJ maintenance and repair in aging.衰老过程中的神经肌肉接头维持与修复
Curr Opin Physiol. 2018 Aug;4:57-64. doi: 10.1016/j.cophys.2018.05.007. Epub 2018 Jun 11.
2
The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.肌肉特异性激酶（MuSK）激活剂聚集蛋白对神经肌肉突触的产后维持具有独立的重要作用。
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16556-61. doi: 10.1073/pnas.1408409111. Epub 2014 Nov 3.
3
Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS.肌纤维分泌FGFBP1以减缓衰老和肌萎缩侧索硬化症进展过程中神经肌肉突触的退化。
J Neurosci. 2017 Jan 4;37(1):70-82. doi: 10.1523/JNEUROSCI.2992-16.2016.
4
The role of glial cells in the formation and maintenance of the neuromuscular junction.神经胶质细胞在神经肌肉接头形成和维持中的作用。
Ann N Y Acad Sci. 2008;1132:19-28. doi: 10.1196/annals.1405.016.
5
Functional adaptation of glial cells at neuromuscular junctions in response to injury.神经肌肉接头处神经胶质细胞对损伤的功能适应性反应。
Glia. 2022 Sep;70(9):1605-1629. doi: 10.1002/glia.24184. Epub 2022 Apr 27.
6
Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction.终末施万细胞衰老：对年龄相关神经肌肉功能障碍的影响。
Aging Dis. 2021 Apr 1;12(2):494-514. doi: 10.14336/AD.2020.0708. eCollection 2021 Apr.
7
Schwann Cells in Neuromuscular Junction Formation and Maintenance.施万细胞在神经肌肉接头形成与维持中的作用
J Neurosci. 2016 Sep 21;36(38):9770-81. doi: 10.1523/JNEUROSCI.0174-16.2016.
8
Milk fat globule membrane supplementation with voluntary running exercise attenuates age-related motor dysfunction by suppressing neuromuscular junction abnormalities in mice.补充乳脂肪球膜并结合自愿跑步运动可通过抑制小鼠神经肌肉接头异常来减轻与年龄相关的运动功能障碍。
Exp Gerontol. 2017 Oct 15;97:29-37. doi: 10.1016/j.exger.2017.07.012. Epub 2017 Jul 18.
9
Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions.细胞和分子证据表明，突触施万细胞有助于小鼠神经肌肉接头的衰老。
Aging Cell. 2023 Nov;22(11):e13981. doi: 10.1111/acel.13981. Epub 2023 Sep 28.
10
Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review.体育锻炼对衰老过程中神经肌肉接头退化的影响：一项系统综述。
J Orthop Translat. 2024 May 23;46:91-102. doi: 10.1016/j.jot.2024.03.007. eCollection 2024 May.
引用本文的文献
1
Episodic denervation as a driver of loss of skeletal muscle redox homeostasis and muscle weakness in sarcopenia: Possible amelioration by exercise.间歇性去神经支配作为肌肉减少症中骨骼肌氧化还原稳态丧失和肌肉无力的驱动因素：运动可能的改善作用
Sports Med Health Sci. 2025 Feb 7;7(5):341-350. doi: 10.1016/j.smhs.2025.02.002. eCollection 2025 Sep.
2
Heat Shock Proteins: Important Helpers for the Development, Maintenance and Regeneration of Skeletal Muscles.热休克蛋白：骨骼肌发育、维持和再生的重要帮手
Muscles. 2023 Apr 18;2(2):187-203. doi: 10.3390/muscles2020014.
3
Aging in the Skeletal Muscle Revealed by Molecular Immunohistochemical Imaging.分子免疫组织化学成像揭示骨骼肌衰老
Int J Mol Sci. 2025 Jun 22;26(13):5986. doi: 10.3390/ijms26135986.
4
AMPK regulates the maintenance and remodelling of the neuromuscular junction.腺苷酸活化蛋白激酶（AMPK）调节神经肌肉接头的维持与重塑。
Mol Metab. 2025 Jan;91:102066. doi: 10.1016/j.molmet.2024.102066. Epub 2024 Nov 19.
5
Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review.体育锻炼对衰老过程中神经肌肉接头退化的影响：一项系统综述。
J Orthop Translat. 2024 May 23;46:91-102. doi: 10.1016/j.jot.2024.03.007. eCollection 2024 May.
6
Origin, identity, and function of terminal Schwann cells.终端许旺细胞的起源、特性和功能。
Trends Neurosci. 2024 Jun;47(6):432-446. doi: 10.1016/j.tins.2024.03.007. Epub 2024 Apr 24.
7
Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling.解码神经肌肉接头重塑过程中肌肉驻留雪旺细胞的动态变化。
bioRxiv. 2025 May 20:2023.10.06.561193. doi: 10.1101/2023.10.06.561193.
8
Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice.在进行体力活动的 HET3 小鼠中，鼠遗传品系背景对与年龄相关表型的影响。
Neurobiol Aging. 2024 Apr;136:58-69. doi: 10.1016/j.neurobiolaging.2024.01.010. Epub 2024 Jan 30.
9
Alterations in neuromuscular junction morphology with ageing and endurance training modulate neuromuscular transmission and myofibre composition.随着年龄增长和耐力训练，神经肌肉接头形态的改变会调节神经肌肉传递和肌纤维组成。
J Physiol. 2025 Jan;603(1):107-125. doi: 10.1113/JP285143. Epub 2024 Jan 3.
10
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men.人类骨骼肌衰老的特征及其对理解女性和男性肌肉减少症病理生理学的意义。
Clin Sci (Lond). 2023 Nov 29;137(22):1721-1751. doi: 10.1042/CS20230319.
本文引用的文献
1
Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury.胶原 XIII 对于周围神经损伤后的神经肌肉突触再生和功能恢复是必需的。
J Neurosci. 2018 Apr 25;38(17):4243-4258. doi: 10.1523/JNEUROSCI.3119-17.2018. Epub 2018 Apr 6.
2
SIRT1 regulates nuclear number and domain size in skeletal muscle fibers.SIRT1 调节骨骼肌纤维中的核数和域大小。
J Cell Physiol. 2018 Sep;233(9):7157-7163. doi: 10.1002/jcp.26542. Epub 2018 Mar 25.
3
Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men.未能扩大运动单位大小以补偿运动单位数量的下降，将肌少症与非肌少症的老年男性区分开来。
J Physiol. 2018 May 1;596(9):1627-1637. doi: 10.1113/JP275520. Epub 2018 Mar 23.
4
Overexpression of PGC-1α in aging muscle enhances a subset of young-like molecular patterns.PGC-1α 在衰老肌肉中的过表达增强了一组类似年轻的分子模式。
Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12707. Epub 2018 Feb 10.
5
The Composition, Development, and Regeneration of Neuromuscular Junctions.神经肌肉接头的组成、发育和再生。
Curr Top Dev Biol. 2018;126:99-124. doi: 10.1016/bs.ctdb.2017.08.005. Epub 2017 Nov 10.
6
Age-related changes in the structure and function of mammalian neuromuscular junctions.哺乳动物神经肌肉接头结构和功能的年龄相关性变化。
Ann N Y Acad Sci. 2018 Jan;1412(1):41-53. doi: 10.1111/nyas.13521. Epub 2017 Dec 31.
7
Neuromuscular Junction Formation, Aging, and Disorders.神经肌肉接头的形成、衰老和疾病。
Annu Rev Physiol. 2018 Feb 10;80:159-188. doi: 10.1146/annurev-physiol-022516-034255. Epub 2017 Dec 1.
8
Cellular and Molecular Anatomy of the Human Neuromuscular Junction.人体神经肌肉接头的细胞和分子解剖结构
Cell Rep. 2017 Nov 28;21(9):2348-2356. doi: 10.1016/j.celrep.2017.11.008.
9
Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging.单肌纤维蛋白质组学揭示人类肌肉衰老的纤维类型特异性特征。
Cell Rep. 2017 Jun 13;19(11):2396-2409. doi: 10.1016/j.celrep.2017.05.054.
10
Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration.成年骨骼肌干细胞的丧失会导致与年龄相关的神经肌肉接头退化。
Elife. 2017 Jun 6;6:e26464. doi: 10.7554/eLife.26464.
Zotero 插件