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诺氟沙星治疗复杂性尿路感染24周与诺氟沙星治疗12周后再用安慰剂治疗12周的双盲随机对照研究

Double-blind, randomized comparison of 24 weeks of norfloxacin and 12 weeks of norfloxacin followed by 12 weeks of placebo in the therapy of complicated urinary tract infection.

作者信息

Sheehan G J, Harding G K, Haase D A, Thomson M J, Urias B, Kennedy J K, Hoban D J, Ronald A R

机构信息

Department of Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Antimicrob Agents Chemother. 1988 Aug;32(8):1292-3. doi: 10.1128/AAC.32.8.1292.

DOI:10.1128/AAC.32.8.1292
PMID:3056259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172398/
Abstract

We evaluated the benefits of prolonging norfloxacin therapy from 12 to 24 weeks for complicated urinary tract infection in a double-blind, randomized, placebo-controlled study. During the second 12 weeks, norfloxacin was superior to placebo (P less than 0.05) in suppressing bacteriuria. Adverse effects were common but mostly confined to the initial 12 weeks.

摘要

在一项双盲、随机、安慰剂对照研究中，我们评估了将诺氟沙星治疗复杂尿路感染的疗程从12周延长至24周的益处。在第二个12周期间，诺氟沙星在抑制菌尿方面优于安慰剂（P<0.05）。不良反应常见，但大多局限于最初的12周。

相似文献

1
Double-blind, randomized comparison of 24 weeks of norfloxacin and 12 weeks of norfloxacin followed by 12 weeks of placebo in the therapy of complicated urinary tract infection.诺氟沙星治疗复杂性尿路感染24周与诺氟沙星治疗12周后再用安慰剂治疗12周的双盲随机对照研究
Antimicrob Agents Chemother. 1988 Aug;32(8):1292-3. doi: 10.1128/AAC.32.8.1292.
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Double-blind comparison of 3-day versus 7-day treatment with norfloxacin in symptomatic urinary tract infections. The Inter-Nordic Urinary Tract Infection Study Group.
Scand J Infect Dis. 1988;20(6):619-24. doi: 10.3109/00365548809035662.
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[Comparative evaluation of norfloxacin and cinoxacin in the therapy of complicated infections of the urinary tract].诺氟沙星与西诺沙星治疗复杂性尿路感染的比较评价
Minerva Med. 1989 Apr;80(4):393-5.
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Single-dose compared with 3-day norfloxacin treatment of uncomplicated urinary tract infection in women. Canadian Infectious Diseases Society Clinical Trials Study Group.单剂量与3日诺氟沙星治疗女性单纯性尿路感染的比较。加拿大传染病协会临床试验研究组。
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Fosfomycin trometamol in a single dose versus norfloxacin for seven days in the treatment of uncomplicated urinary infections in general practice.在普通医疗实践中，单剂量的磷霉素氨丁三醇与诺氟沙星治疗7天用于治疗单纯性泌尿系统感染的比较。
Infection. 1990;18 Suppl 2:S80-8. doi: 10.1007/BF01643433.
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Coordinated multicenter study of norfloxacin versus trimethoprim-sulfamethoxazole treatment of symptomatic urinary tract infections. The Urinary Tract Infection Study Group.
J Infect Dis. 1987 Feb;155(2):170-7. doi: 10.1093/infdis/155.2.170.

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Antimicrob Agents Chemother. 1989 Oct;33(10):1662-7. doi: 10.1128/AAC.33.10.1662.
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本文引用的文献

1
Long-term therapy for chronic bacteriuria in men. U.S. Public Health Service cooperative study.男性慢性菌尿的长期治疗。美国公共卫生服务合作研究。
Ann Intern Med. 1975 Aug;83(2):133-47. doi: 10.7326/0003-4819-83-2-133.
2
Renal stones and urinary infection: a study of antibiotic treatment.肾结石与泌尿系统感染：抗生素治疗的一项研究
Br Med J. 1976 Dec 11;2(6049):1411-3. doi: 10.1136/bmj.2.6049.1411.