Chinn R H, Maskell R, Mead J A, Polak A
Br Med J. 1976 Dec 11;2(6049):1411-3. doi: 10.1136/bmj.2.6049.1411.
Twenty-two patients in whom renal calculi and urinary infection were closely associated were studied over two to five years. Four patients had previously had stones surgically removed, and five underwent pyelolithotomy during the course of the study. Urinary infection was treated with an appropriate antibacterial agent, and treatment was followed by long-term prophylaxis, usually with cotrimoxazole. A sterile urine was maintained for long periods in all these patients. In four patients, however, apparent stone growth occurred while the urine was sterile. On entering the study 21 of the 22 patients complained of symptoms. After treatment 19 of the 20 patients who were still attending were symptom-free. Six of the 22 patients entered the study with raised levels of serum creatinine; levels fell in four and remained raised in two. This antibacterial regimen, either alone or after surgery, will usually relieve symptoms and may prevent deterioration of renal function.
对22例肾结石与泌尿系统感染密切相关的患者进行了为期两到五年的研究。4例患者先前已通过手术取出结石，5例在研究过程中接受了肾盂切开取石术。泌尿系统感染采用适当的抗菌药物治疗，治疗后进行长期预防，通常使用复方新诺明。所有这些患者都长期保持尿液无菌。然而，有4例患者在尿液无菌的情况下结石明显增大。22例患者中有21例在进入研究时诉说有症状。在仍在接受治疗的20例患者中，19例在治疗后无症状。22例患者中有6例进入研究时血清肌酐水平升高；4例水平下降，2例仍升高。这种抗菌方案，无论是单独使用还是在手术后使用，通常都能缓解症状，并可能防止肾功能恶化。
