Iino Tadafumi, Takaishi Shigeo
Nihon Rinsho. 2017 Feb;75(2):306-311.
Natural killer (NK) cells are innate lymphoid cells important for host defense against patho- gens, and are also thought to play an important role in the immunosurveillance against can- cers. NK cells express surface receptors that interact with target cells and determine their response to infected or transformed cells without prior sensitization or gene rearrangement. Activated NK cells can kill target cells by producing effector molecules and transmit impor- tant information to the rest of the immune system subsequently by producing cytokines. Here, we review the mechanism of cytotoxic function of NK cells and a recent development in NK cell biology, and highlight therapeutic approaches for NK cell-based immunotherapy and targeting NK cells in the treatment of cancer. //.
自然杀伤（NK）细胞是先天性淋巴细胞，对宿主抵御病原体至关重要，也被认为在针对癌症的免疫监视中发挥重要作用。NK细胞表达与靶细胞相互作用的表面受体，可在无需预先致敏或基因重排的情况下决定其对受感染或转化细胞的反应。活化的NK细胞可通过产生效应分子来杀伤靶细胞，并随后通过产生细胞因子将重要信息传递给免疫系统的其他部分。在此，我们综述NK细胞细胞毒性功能的机制以及NK细胞生物学的最新进展，并着重介绍基于NK细胞的免疫疗法的治疗方法以及在癌症治疗中靶向NK细胞的方法。
