School of Medicine, Huaqiao University, Quanzhou 362021, Fujian, China.
Int J Mol Sci. 2019 Jan 14;20(2):317. doi: 10.3390/ijms20020317.
Natural killer (NK) cells are innate immune cells that can be activated rapidly to target abnormal and virus-infected cells without prior sensitization. With significant advancements in cell biology technologies, many NK cell lines have been established. Among these cell lines, NK-92 cells are not only the most widely used but have also been approved for clinical applications. Additionally, chimeric antigen receptor-modified NK-92 cells (CAR-NK-92 cells) have shown strong antitumor effects. In this review, we summarize established human NK cell lines and their biological characteristics, and highlight the applications of NK-92 cells and CAR-NK-92 cells in tumor immunotherapy.
自然杀伤 (NK) 细胞是先天免疫细胞，无需预先致敏即可快速激活以靶向异常和病毒感染的细胞。随着细胞生物学技术的重大进展，已经建立了许多 NK 细胞系。在这些细胞系中，NK-92 细胞不仅应用最广泛，而且已经获得临床批准。此外，嵌合抗原受体修饰的 NK-92 细胞（CAR-NK-92 细胞）已显示出强大的抗肿瘤作用。在这篇综述中，我们总结了已建立的人 NK 细胞系及其生物学特性，并强调了 NK-92 细胞和 CAR-NK-92 细胞在肿瘤免疫治疗中的应用。
