Otun Sarah, Achilonu Ikechukwu, Odero-Marah Valerie
School of Molecular and Cell Biology, Faculty of Science, Protein Structure-Function and Research Unit, University of the Witwatersrand, Braamfontein, Johannesburg, South Africa.
Center for Urban Health Disparities Research and Innovation, Department of Biology, Morgan State University, Baltimore MD 21251, United States.
J Funct Foods. 2024 May;116. doi: 10.1016/j.jff.2024.106146. Epub 2024 Apr 6.
The use of muscadine grape extracts (MGSE). in cancer treatment has gained attention due to its distinctive composition of polyphenols and antioxidants. This review analyses the reported anti-cancer properties of MGSE. The study commences by reviewing the phytochemical composition of MGSE, highlighting the presence of resveratrol and ellagic acid. Furthermore, the review underscores the mechanism of action of these active compounds in MGSE in combating cancer cells. The anti-cancer potential of MGSE compared to other plant extracts is also discussed. In addition, it highlights MGSE's superiority and distinct phytochemical composition in preventing cancer growth by comparing its anti-cancer compounds with those of other anti-cancer medicinal plants. Lastly, the combinatory approaches of MGSE with traditional cancer therapies, its safety, and its possible side effects were highlighted. This work provides an understanding of the anti-cancer properties of MGSE, positioning it as a valuable and unique challenge within the field of cancer therapy.
由于其独特的多酚和抗氧化剂成分，麝香葡萄提取物（MGSE）在癌症治疗中的应用受到了关注。本综述分析了MGSE已报道的抗癌特性。该研究首先回顾了MGSE的植物化学成分，强调了白藜芦醇和鞣花酸的存在。此外，该综述强调了MGSE中这些活性化合物对抗癌细胞的作用机制。还讨论了MGSE与其他植物提取物相比的抗癌潜力。此外，通过将其抗癌化合物与其他抗癌药用植物的化合物进行比较，突出了MGSE在预防癌症生长方面的优越性和独特的植物化学成分。最后，强调了MGSE与传统癌症疗法的联合应用方法、其安全性及其可能的副作用。这项工作有助于了解MGSE的抗癌特性，使其成为癌症治疗领域中一个有价值且独特的挑战。
