与急性肝损伤相关的减肥草药补充剂Safe Lean™的化学分析——对假药、标签错误和掺假的关注。
Chemical Analysis of Weight Loss Herbal Supplement Safe Lean™ Associated With Acute Liver Injury - A Concern for Spurious Drug, Misbranding and Adulteration.
作者信息
Philips Cyriac A, Augustine Philip
机构信息
The Liver Unit, Cochin Gastroenterology Group, Ernakulam Medical Centre, Kochi 682028, Kerala, India.
出版信息
J Clin Exp Hepatol. 2018 Dec;8(4):471-473. doi: 10.1016/j.jceh.2018.05.001. Epub 2018 May 17.
Abstract
Liver injury due to herbal and dietary supplements are well described in literature and its incidence has been on the rise in the past decade. Labelling an herbal product as non-medicinal and as a supplement precludes protocols needed for testing, trials and marketing criteria. This has led to rampant use of clinically unproven multi-herb-based drugs use for a myriad of lifestyle diseases. In this report, we discuss a new dietary weight loss supplement, Safe Lean™ that was found to be the cause of liver injury in a young obese woman, that resolved after discontinuation, and discuss current literature on component, toxicology and chemical analysis of the offending drug.
摘要
草药和膳食补充剂导致的肝损伤在文献中已有充分描述，且在过去十年中其发病率一直在上升。将草药产品标记为非药用和补充剂，排除了测试、试验和营销标准所需的方案。这导致了临床上未经证实的多种草药药物被大量用于治疗各种生活方式疾病。在本报告中，我们讨论了一种新的膳食减肥补充剂Safe Lean™，它被发现是一名年轻肥胖女性肝损伤的原因，停药后肝损伤得到缓解，并讨论了关于该有害药物的成分、毒理学和化学分析的现有文献。
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