纳米技术在男性生育能力和精子功能方面的应用前景。
Perspectives of nanotechnology in male fertility and sperm function.
作者信息
Falchi Laura, Khalil Wael A, Hassan Mahmoud, Marei Waleed F A
机构信息
Dipartimento di Medicina Veterinaria, Sezione di Clinica Ostetrica e Ginecologia, Università di Sassari, Sassari, Italy.
Department of Animal Production, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt.
出版信息
Int J Vet Sci Med. 2018 Sep 12;6(2):265-269. doi: 10.1016/j.ijvsm.2018.09.001. eCollection 2018 Dec.
Recent advances in nanotechnology have tremendously expanded its possible applications in biomedicine. Although, the effects of nanoparticles (NPs) at cellular and tissue levels have not been fully understood, some of these biological effects might be employed in assisted reproduction to improve male fertility particularly by enhancing sperm cell quality either or . This review summarises the available literature regarding the potential applications of nanomaterials in farm animal reproduction, with a specific focus on the male gamete and on different strategies to improve breeding performances, transgenesis and targeted delivery of substances to a sperm cell. Antioxidant, antimicrobial properties and special surface binding ligand functionalization and their applications for sperm processing and cryopreservation have been reviewed. In addition, nanotoxicity and detrimental effects of NPs on sperm cells are also discussed due to the increasing concerns regarding the environmental impact of the expanding use of nanotechnologies on reproduction.
纳米技术的最新进展极大地扩展了其在生物医学中的潜在应用。尽管纳米颗粒（NPs）在细胞和组织水平上的作用尚未完全了解，但其中一些生物学效应可用于辅助生殖，特别是通过改善精子细胞质量来提高男性生育能力。本文综述了有关纳米材料在农场动物繁殖中潜在应用的现有文献，特别关注雄配子以及提高繁殖性能、转基因和向精子细胞靶向递送物质的不同策略。综述了抗氧化、抗菌特性以及特殊表面结合配体功能化及其在精子处理和冷冻保存中的应用。此外，由于人们越来越关注纳米技术广泛应用对生殖的环境影响，还讨论了纳米颗粒的纳米毒性及其对精子细胞的有害影响。
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